Insider access: pepducin symposium explores a new approach to GPCR modulation

Jacquelyn Miller; Anika Agarwal; Lakshmi A. Devi; Kellen Fontanini; James A. Hamilton; Jean-Philippe Pin; Denis C. Shields; C. Arnold Spek; Thomas P. Sakmar; Athan Kuliopulos; Stephen W. Hunt

doi:https://doi.org/10.1111/j.1749-6632.2009.05326.x

Insider access: pepducin symposium explores a new approach to GPCR modulation

Jacquelyn Miller, Anika Agarwal, Lakshmi A. Devi, Kellen Fontanini, James A. Hamilton, Jean-Philippe Pin, Denis C. Shields, C. Arnold Spek, Thomas P. Sakmar, Athan Kuliopulos, Stephen W. Hunt

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

Abstract

The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8-9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein-coupled receptor-related research. G protein-coupled receptors (GPCRs) are, arguably, one of the most important molecular targets in drug discovery and pharmaceutical development today. This superfamily of membrane receptors is central to nearly every signaling pathway in the human body and has been the focus of intense research for decades. However, as scientists discover additional properties of GPCRs, it has become clear that much is yet to be understood about how these receptors function. Everyone agrees, however, that tremendous potential remains if specific GPCR signaling pathways can be modulated to correct pathological states. One exciting new approach to this challenge involves pepducins: novel, synthetic lipopeptide pharmacophores that modulate heptahelical GPCR activity from inside the cell membrane

Original language	English
Pages (from-to)	E1-12
Journal	Annals of the New York Academy of Sciences
Volume	1180
Issue number	Suppl. 1
DOIs	https://doi.org/10.1111/j.1749-6632.2009.05326.x
Publication status	Published - 2009

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https://doi.org/10.1111/j.1749-6632.2009.05326.x

Cite this

@article{fbc85b4c50344231b033e6383bd38a58,

title = "Insider access: pepducin symposium explores a new approach to GPCR modulation",

abstract = "The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8-9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein-coupled receptor-related research. G protein-coupled receptors (GPCRs) are, arguably, one of the most important molecular targets in drug discovery and pharmaceutical development today. This superfamily of membrane receptors is central to nearly every signaling pathway in the human body and has been the focus of intense research for decades. However, as scientists discover additional properties of GPCRs, it has become clear that much is yet to be understood about how these receptors function. Everyone agrees, however, that tremendous potential remains if specific GPCR signaling pathways can be modulated to correct pathological states. One exciting new approach to this challenge involves pepducins: novel, synthetic lipopeptide pharmacophores that modulate heptahelical GPCR activity from inside the cell membrane",

author = "Jacquelyn Miller and Anika Agarwal and Devi, {Lakshmi A.} and Kellen Fontanini and Hamilton, {James A.} and Jean-Philippe Pin and Shields, {Denis C.} and Spek, {C. Arnold} and Sakmar, {Thomas P.} and Athan Kuliopulos and Hunt, {Stephen W.}",

year = "2009",

doi = "https://doi.org/10.1111/j.1749-6632.2009.05326.x",

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journal = "Annals of the New York Academy of Sciences",

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T1 - Insider access: pepducin symposium explores a new approach to GPCR modulation

AU - Miller, Jacquelyn

AU - Agarwal, Anika

AU - Devi, Lakshmi A.

AU - Fontanini, Kellen

AU - Hamilton, James A.

AU - Pin, Jean-Philippe

AU - Shields, Denis C.

AU - Spek, C. Arnold

AU - Sakmar, Thomas P.

AU - Kuliopulos, Athan

AU - Hunt, Stephen W.

PY - 2009

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AB - The inaugural Pepducin Science Symposium convened in Cambridge, Massachusetts on March 8-9, 2009 provided the opportunity for an international group of distinguished scientists to present and discuss research regarding G protein-coupled receptor-related research. G protein-coupled receptors (GPCRs) are, arguably, one of the most important molecular targets in drug discovery and pharmaceutical development today. This superfamily of membrane receptors is central to nearly every signaling pathway in the human body and has been the focus of intense research for decades. However, as scientists discover additional properties of GPCRs, it has become clear that much is yet to be understood about how these receptors function. Everyone agrees, however, that tremendous potential remains if specific GPCR signaling pathways can be modulated to correct pathological states. One exciting new approach to this challenge involves pepducins: novel, synthetic lipopeptide pharmacophores that modulate heptahelical GPCR activity from inside the cell membrane

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DO - https://doi.org/10.1111/j.1749-6632.2009.05326.x

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