Abstract
The intercellular adhesion molecule-1 (ICAM-1) has an important role in the process of lymphocyte migration and activation, and is supposed to be involved in the pathogenesis of type 1 diabetes. We studied A/G (K469E) polymorphism of the ICAM-1 gene in 218 type 1 diabetes patients and 212 controls from Finland and found no association. We then studied transmission of the ICAM-1 alleles in 102 Finnish families using a transmission disequilibrium test (TDT). Alleles A and G were transmitted to the affected offspring in 50% each. Stratification by the HLA-DQB1-DQA1 genotypes, sex and age at onset did not reveal association. Our data demonstrate that in the Finnish population K469E polymorphism of the ICAM-1 gene is not associated with type 1 diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 568-70 |
| Number of pages | 3 |
| Journal | Tissue antigens |
| Volume | 55 |
| Issue number | 6 |
| Publication status | Published - Jun 2000 |
| Externally published | Yes |
Keywords
- Adolescent
- Alleles
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1/epidemiology
- Female
- Finland/epidemiology
- Gene Frequency
- Glutamic Acid/genetics
- Humans
- Infant
- Infant, Newborn
- Intercellular Adhesion Molecule-1/genetics
- Lysine/genetics
- Male
- Polymorphism, Genetic/genetics