Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis

Sergey Nejentsev; Mikko Laaksonen; Pentti J Tienari; Oscar Fernandez; Heather Cordell; Juhani Ruutiainen; Juhani Wikström; Tomi Pastinen; Satu Kuokkanen; Jan Hillert; Jorma Ilonen

Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis

Sergey Nejentsev, Mikko Laaksonen, Pentti J Tienari, Oscar Fernandez, Heather Cordell, Juhani Ruutiainen, Juhani Wikström, Tomi Pastinen, Satu Kuokkanen, Jan Hillert, Jorma Ilonen

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).

Original language	English
Pages (from-to)	345-9
Number of pages	5
Journal	Human immunology
Volume	64
Issue number	3
Publication status	Published - Mar 2003
Externally published	Yes

Keywords

Cohort Studies
Female
Finland/epidemiology
Gene Frequency
Genetic Predisposition to Disease
Humans
Infant, Newborn
Intercellular Adhesion Molecule-1/genetics
Male
Multiple Sclerosis/epidemiology
Polymorphism, Genetic

Cite this

@article{615d870751b941e881aae3c8439773b7,

title = "Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis",

abstract = "Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).",

keywords = "Cohort Studies, Female, Finland/epidemiology, Gene Frequency, Genetic Predisposition to Disease, Humans, Infant, Newborn, Intercellular Adhesion Molecule-1/genetics, Male, Multiple Sclerosis/epidemiology, Polymorphism, Genetic",

author = "Sergey Nejentsev and Mikko Laaksonen and Tienari, {Pentti J} and Oscar Fernandez and Heather Cordell and Juhani Ruutiainen and Juhani Wikstr{\"o}m and Tomi Pastinen and Satu Kuokkanen and Jan Hillert and Jorma Ilonen",

year = "2003",

month = mar,

language = "English",

volume = "64",

pages = "345--9",

journal = "Human immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Intercellular adhesion molecule-1 K469E polymorphism

T2 - study of association with multiple sclerosis

AU - Nejentsev, Sergey

AU - Laaksonen, Mikko

AU - Tienari, Pentti J

AU - Fernandez, Oscar

AU - Cordell, Heather

AU - Ruutiainen, Juhani

AU - Wikström, Juhani

AU - Pastinen, Tomi

AU - Kuokkanen, Satu

AU - Hillert, Jan

AU - Ilonen, Jorma

PY - 2003/3

Y1 - 2003/3

N2 - Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).

AB - Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenesis of multiple sclerosis (MS), whereas sequence variations in the ICAM-1 gene could potentially be responsible for the genetic susceptibility to MS. We studied an association of MS with the 13,848A>G (K469E) polymorphism of the ICAM-1 gene in Finnish and Spanish cases and controls and affected families. An increased risk for the AA (Lys(469)/Lys(469)) genotype was found in both populations. The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).

KW - Cohort Studies

KW - Female

KW - Finland/epidemiology

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Infant, Newborn

KW - Intercellular Adhesion Molecule-1/genetics

KW - Male

KW - Multiple Sclerosis/epidemiology

KW - Polymorphism, Genetic

M3 - Article

C2 - 12590979

SN - 0198-8859

VL - 64

SP - 345

EP - 349

JO - Human immunology

JF - Human immunology

IS - 3

ER -