Abstract
Original language | English |
---|---|
Pages (from-to) | 4558 |
Journal | Nature communications |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2019 |
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Nature communications, Vol. 10, No. 1, 01.12.2019, p. 4558.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
AU - Nievergelt, Caroline M.
AU - Maihofer, Adam X.
AU - Klengel, Torsten
AU - Atkinson, Elizabeth G.
AU - Chen, Chia-Yen
AU - Choi, Karmel W.
AU - Coleman, Jonathan R. I.
AU - Dalvie, Shareefa
AU - Duncan, Laramie E.
AU - Gelernter, Joel
AU - Levey, Daniel F.
AU - Logue, Mark W.
AU - Polimanti, Renato
AU - Provost, Allison C.
AU - Ratanatharathorn, Andrew
AU - Stein, Murray B.
AU - Torres, Katy
AU - Aiello, Allison E.
AU - Almli, Lynn M.
AU - Amstadter, Ananda B.
AU - Andersen, S. ren B.
AU - Andreassen, Ole A.
AU - Arbisi, Paul A.
AU - Ashley-Koch, Allison E.
AU - Austin, S. Bryn
AU - Avdibegovic, Esmina
AU - Babić, Dragan
AU - Bækvad-Hansen, Marie
AU - Baker, Dewleen G.
AU - Beckham, Jean C.
AU - Bierut, Laura J.
AU - Bisson, Jonathan I.
AU - Boks, Marco P.
AU - Bolger, Elizabeth A.
AU - Børglum, Anders D.
AU - Bradley, Bekh
AU - Brashear, Megan
AU - Breen, Gerome
AU - Bryant, Richard A.
AU - Bustamante, Angela C.
AU - Bybjerg-Grauholm, Jonas
AU - Calabrese, Joseph R.
AU - Caldas-de-Almeida, José M.
AU - Dale, Anders M.
AU - Daly, Mark J.
AU - Daskalakis, Nikolaos P.
AU - Deckert, J. rgen
AU - Delahanty, Douglas L.
AU - Dennis, Michelle F.
AU - Disner, Seth G.
AU - Domschke, Katharina
AU - Dzubur-Kulenovic, Alma
AU - Erbes, Christopher R.
AU - Evans, Alexandra
AU - Farrer, Lindsay A.
AU - Feeny, Norah C.
AU - Flory, Janine D.
AU - Forbes, David
AU - Franz, Carol E.
AU - Galea, Sandro
AU - Garrett, Melanie E.
AU - Gelaye, Bizu
AU - Geuze, Elbert
AU - Gillespie, Charles
AU - Uka, Aferdita Goci
AU - Gordon, Scott D.
AU - Guffanti, Guia
AU - Hammamieh, Rasha
AU - Harnal, Supriya
AU - Hauser, Michael A.
AU - Heath, Andrew C.
AU - Hemmings, Sian M. J.
AU - Hougaard, David Michael
AU - Jakovljevic, Miro
AU - Jett, Marti
AU - Johnson, Eric Otto
AU - Jones, Ian
AU - Jovanovic, Tanja
AU - Qin, Xue-Jun
AU - Junglen, Angela G.
AU - Karstoft, Karen-Inge
AU - Kaufman, Milissa L.
AU - Kessler, Ronald C.
AU - Khan, Alaptagin
AU - Kimbrel, Nathan A.
AU - King, Anthony P.
AU - Koen, Nastassja
AU - Kranzler, Henry R.
AU - Kremen, William S.
AU - Lawford, Bruce R.
AU - Lebois, Lauren A. M.
AU - Lewis, Catrin E.
AU - Linnstaedt, Sarah D.
AU - Lori, Adriana
AU - Lugonja, Bozo
AU - Luykx, Jurjen J.
AU - Lyons, Michael J.
AU - Maples-Keller, Jessica
AU - Marmar, Charles
AU - Martin, Alicia R.
AU - Martin, Nicholas G.
AU - Maurer, Douglas
AU - Mavissakalian, Matig R.
AU - McFarlane, Alexander
AU - McGlinchey, Regina E.
AU - McLaughlin, Katie A.
AU - McLean, Samuel A.
AU - McLeay, Sarah
AU - Mehta, Divya
AU - Milberg, William P.
AU - Miller, Mark W.
AU - Morey, Rajendra A.
AU - Morris, Charles Phillip
AU - Mors, Ole
AU - Mortensen, Preben B.
AU - Neale, Benjamin M.
AU - Nelson, Elliot C.
AU - Nordentoft, Merete
AU - Norman, Sonya B.
AU - O'Donnell, Meaghan
AU - Orcutt, Holly K.
AU - Panizzon, Matthew S.
AU - Peters, Edward S.
AU - Peterson, Alan L.
AU - Peverill, Matthew
AU - Pietrzak, Robert H.
AU - Polusny, Melissa A.
AU - Rice, John P.
AU - Ripke, Stephan
AU - Risbrough, Victoria B.
AU - Roberts, Andrea L.
AU - Rothbaum, Alex O.
AU - Rothbaum, Barbara O.
AU - Roy-Byrne, Peter
AU - Ruggiero, Ken
AU - Rung, Ariane
AU - Rutten, Bart P. F.
AU - Saccone, Nancy L.
AU - Sanchez, Sixto E.
AU - Schijven, Dick
AU - Seedat, Soraya
AU - Seligowski, Antonia V.
AU - Seng, Julia S.
AU - Sheerin, Christina M.
AU - Silove, Derrick
AU - Smith, Alicia K.
AU - Smoller, Jordan W.
AU - Sponheim, Scott R.
AU - Stein, Dan J.
AU - Stevens, Jennifer S.
AU - Sumner, Jennifer A.
AU - Teicher, Martin H.
AU - Thompson, Wesley K.
AU - Trapido, Edward
AU - Uddin, Monica
AU - Ursano, Robert J.
AU - van den Heuvel, Leigh Luella
AU - van Hooff, Miranda
AU - Vermetten, Eric
AU - Vinkers, Christiaan H.
AU - Voisey, Joanne
AU - Wang, Yunpeng
AU - Wang, Zhewu
AU - Werge, Thomas
AU - Williams, Michelle A.
AU - Williamson, Douglas E.
AU - Winternitz, Sherry
AU - Wolf, Christiane
AU - Wolf, Erika J.
AU - Wolff, Jonathan D.
AU - Yehuda, Rachel
AU - Young, Ross McD
AU - Young, Keith A.
AU - Zhao, Hongyu
AU - Zoellner, Lori A.
AU - Liberzon, Israel
AU - Ressler, Kerry J.
AU - Haas, Magali
AU - Koenen, Karestan C.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.
AB - The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073062147&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31594949
U2 - https://doi.org/10.1038/s41467-019-12576-w
DO - https://doi.org/10.1038/s41467-019-12576-w
M3 - Article
C2 - 31594949
SN - 2041-1723
VL - 10
SP - 4558
JO - Nature communications
JF - Nature communications
IS - 1
ER -