TY - JOUR
T1 - Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression
AU - Mosterd, C. M.
AU - Kanbay, M.
AU - van den Born, B. J. H.
AU - van Raalte, D. H.
AU - Rampanelli, E.
N1 - Funding Information: The writing of this review was funded by a Top Consortia for Knowledge and Innovation (TKI-PPP) grant (Health-Holland, 2020) awarded to E.Rampanelli. Publisher Copyright: © 2021 The Author(s)
PY - 2021/5
Y1 - 2021/5
N2 - Diabetic kidney disease (DKD) represents a growing public health burden and is the leading cause of end-stage kidney diseases. In recent years, host-gut microbiota interactions have emerged as an integral part for host homeostasis. In the context of nephropathies, mounting evidence supports a bidirectional microbiota-kidney crosstalk, which becomes particularly manifest during progressive kidney dysfunction. Indeed, in chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened. In this review, we will summarize the evidence from clinical/experimental studies concerning the occurrence of gut dysbiosis in diabetic and non-diabetic CKD, discuss the functional consequences of dysbiosis for CKD progression and debate putative therapeutic interventions targeting the intestinal microbiome.
AB - Diabetic kidney disease (DKD) represents a growing public health burden and is the leading cause of end-stage kidney diseases. In recent years, host-gut microbiota interactions have emerged as an integral part for host homeostasis. In the context of nephropathies, mounting evidence supports a bidirectional microbiota-kidney crosstalk, which becomes particularly manifest during progressive kidney dysfunction. Indeed, in chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened. In this review, we will summarize the evidence from clinical/experimental studies concerning the occurrence of gut dysbiosis in diabetic and non-diabetic CKD, discuss the functional consequences of dysbiosis for CKD progression and debate putative therapeutic interventions targeting the intestinal microbiome.
KW - chronic kidney disease
KW - diabetic kidney disease
KW - inflammation
KW - metabolites
KW - microbiota
UR - http://www.scopus.com/inward/record.url?scp=85100411930&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.beem.2021.101484
DO - https://doi.org/10.1016/j.beem.2021.101484
M3 - Review article
C2 - 33546983
SN - 1521-690X
VL - 35
JO - Best practice & research. Clinical endocrinology & metabolism
JF - Best practice & research. Clinical endocrinology & metabolism
IS - 3
M1 - 101484
ER -