Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

C.N. Black; M. Bot; P.G. Scheffer; P. Cuijpers; B.W.J.H. Penninx

doi:https://doi.org/10.1016/j.psyneuen.2014.09.025

Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

C.N. Black, M. Bot, P.G. Scheffer, P. Cuijpers, B.W.J.H. Penninx

Research output: Contribution to journal › Article › Academic › peer-review

507 Citations (Scopus)

Abstract

Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I

Original language	English
Pages (from-to)	164-175
Journal	Psychoneuroendocrinology
Volume	51
DOIs	https://doi.org/10.1016/j.psyneuen.2014.09.025
Publication status	Published - 2015

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https://doi.org/10.1016/j.psyneuen.2014.09.025

Cite this

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title = "Is depression associated with increased oxidative stress? A systematic review and meta-analysis.",

abstract = "Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I",

author = "C.N. Black and M. Bot and P.G. Scheffer and P. Cuijpers and B.W.J.H. Penninx",

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T1 - Is depression associated with increased oxidative stress? A systematic review and meta-analysis.

AU - Black, C.N.

AU - Bot, M.

AU - Scheffer, P.G.

AU - Cuijpers, P.

AU - Penninx, B.W.J.H.

PY - 2015

Y1 - 2015

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AB - Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes, measures of oxidative DNA and lipid damage respectively, are among the most reliable oxidative stress markers, but studies on their association with depression show conflicting results. This meta-analysis quantifies the association between depression and these markers and explores factors that may explain inconsistencies in the results. Methods: A systematic literature search was conducted in PubMed, EMBASE and PsycINFO. Studies assessing the association of 8-OHdG or F2-isoprostanes with elevated depressive symptoms, major depressive disorder (MDD) or bipolar disorder (BD) were pooled in two random-effect models. Results: The pooled effect size (Hedges' g) for the association of depression with oxidative stress was 0.31 (p=0.01, I

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DO - https://doi.org/10.1016/j.psyneuen.2014.09.025

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