Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research

M.-P. van de Kerkhove; R. Hoekstra; T. M. van Gulik; R. A. F. M. Chamuleau

doi:https://doi.org/10.1016/S0142-9612(03)00509-X

Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research

M.-P. van de Kerkhove, R. Hoekstra, T. M. van Gulik, R. A. F. M. Chamuleau

Research output: Contribution to journal › Review article › Academic › peer-review

46 Citations (Scopus)

Abstract

Among the large range of organs involved in the field of tissue engineering (skin, blood vessels, cartilage, etc.) the liver has been given broad attention in the last decade. Liver support systems encompassing artificial and bioartificial systems are applied to treat patients with fulminant hepatic failure (FHF) as a bridge to orthotopic liver transplantation or to liver regeneration. To test safety, technical applicability and therapeutic effect of liver support systems, reliable animal models are needed. Due to the complexity of FHF many diverse attempts have been made to develop an adequate animal model to study liver failure, liver regeneration and liver support systems. In this paper an overview is given of the different models and their advantages and disadvantages are discussed. Suggestions are made for the most suitable large animal model to test liver support systems. (C) 2003 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	1613-1625
Journal	Biomaterials
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/S0142-9612(03)00509-X
Publication status	Published - 2004

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https://doi.org/10.1016/S0142-9612(03)00509-X

Cite this

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title = "Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research",

abstract = "Among the large range of organs involved in the field of tissue engineering (skin, blood vessels, cartilage, etc.) the liver has been given broad attention in the last decade. Liver support systems encompassing artificial and bioartificial systems are applied to treat patients with fulminant hepatic failure (FHF) as a bridge to orthotopic liver transplantation or to liver regeneration. To test safety, technical applicability and therapeutic effect of liver support systems, reliable animal models are needed. Due to the complexity of FHF many diverse attempts have been made to develop an adequate animal model to study liver failure, liver regeneration and liver support systems. In this paper an overview is given of the different models and their advantages and disadvantages are discussed. Suggestions are made for the most suitable large animal model to test liver support systems. (C) 2003 Elsevier Ltd. All rights reserved",

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T1 - Large animal models of fulminant hepatic failure in artificial and bioartificial liver support research

AU - van de Kerkhove, M.-P.

AU - Hoekstra, R.

AU - van Gulik, T. M.

AU - Chamuleau, R. A. F. M.

PY - 2004

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N2 - Among the large range of organs involved in the field of tissue engineering (skin, blood vessels, cartilage, etc.) the liver has been given broad attention in the last decade. Liver support systems encompassing artificial and bioartificial systems are applied to treat patients with fulminant hepatic failure (FHF) as a bridge to orthotopic liver transplantation or to liver regeneration. To test safety, technical applicability and therapeutic effect of liver support systems, reliable animal models are needed. Due to the complexity of FHF many diverse attempts have been made to develop an adequate animal model to study liver failure, liver regeneration and liver support systems. In this paper an overview is given of the different models and their advantages and disadvantages are discussed. Suggestions are made for the most suitable large animal model to test liver support systems. (C) 2003 Elsevier Ltd. All rights reserved

AB - Among the large range of organs involved in the field of tissue engineering (skin, blood vessels, cartilage, etc.) the liver has been given broad attention in the last decade. Liver support systems encompassing artificial and bioartificial systems are applied to treat patients with fulminant hepatic failure (FHF) as a bridge to orthotopic liver transplantation or to liver regeneration. To test safety, technical applicability and therapeutic effect of liver support systems, reliable animal models are needed. Due to the complexity of FHF many diverse attempts have been made to develop an adequate animal model to study liver failure, liver regeneration and liver support systems. In this paper an overview is given of the different models and their advantages and disadvantages are discussed. Suggestions are made for the most suitable large animal model to test liver support systems. (C) 2003 Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/S0142-9612(03)00509-X

DO - https://doi.org/10.1016/S0142-9612(03)00509-X

M3 - Review article

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SN - 0142-9612

VL - 25

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JO - Biomaterials

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