TY - JOUR
T1 - Late-Life Depression, Cortisol, and the Metabolic Syndrome
AU - Vogelzangs, N.
AU - Beekman, A.T.F.
AU - Dik, M.G.
AU - Bremmer, M.A.
AU - Comijs, H.C.
AU - Hoogendijk, W.J.G.
AU - Deeg, D.J.H.
AU - Penninx, B.W.J.H.
N1 - J English Article Vogelzangs, N, Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands n.vogelzangs@ggzingeest.nl 20 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA AMER J GERIATR PSYCHIATR AUG Discipline: Geriatrics & Gerontology; Gerontology; Psychiatry 476GW
PY - 2009
Y1 - 2009
N2 - OBJECTIVES: High-cortisol levels in depressed persons could possibly give rise to the metabolic syndrome. This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample. METHODS: In 1,212 participants, aged ≤65 years, enrolled in the Longitudinal Aging Study Amsterdam, depression (major [1-month diagnosis] or subthreshold [no 1-month diagnosis, but symptoms]), metabolic syndrome (modified Adult Treatment Panel III criteria), and free cortisol index (total serum cortisol/cortisol binding globulin) were assessed. RESULTS: Major depression was not associated with the metabolic syndrome (odds ratio [OR] = 1.16, 95% confidence interval [CI] = 0.54-2.49), but subthreshold depression was associated with a decreased odds (OR = 0.55, 95% CI = 0.37-0.82). Persons with higher levels of free cortisol index showed a higher odds of metabolic syndrome (OR per standard deviation increase = 1.21, 95% CI = 1.06-1.39). CONCLUSIONS: As persons with high-cortisol levels more often had metabolic syndrome, hypercortisolemia within depressed persons may increase the risk of metabolic syndrome. © 2009 American Association for Geriatric Psychiatry.
AB - OBJECTIVES: High-cortisol levels in depressed persons could possibly give rise to the metabolic syndrome. This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample. METHODS: In 1,212 participants, aged ≤65 years, enrolled in the Longitudinal Aging Study Amsterdam, depression (major [1-month diagnosis] or subthreshold [no 1-month diagnosis, but symptoms]), metabolic syndrome (modified Adult Treatment Panel III criteria), and free cortisol index (total serum cortisol/cortisol binding globulin) were assessed. RESULTS: Major depression was not associated with the metabolic syndrome (odds ratio [OR] = 1.16, 95% confidence interval [CI] = 0.54-2.49), but subthreshold depression was associated with a decreased odds (OR = 0.55, 95% CI = 0.37-0.82). Persons with higher levels of free cortisol index showed a higher odds of metabolic syndrome (OR per standard deviation increase = 1.21, 95% CI = 1.06-1.39). CONCLUSIONS: As persons with high-cortisol levels more often had metabolic syndrome, hypercortisolemia within depressed persons may increase the risk of metabolic syndrome. © 2009 American Association for Geriatric Psychiatry.
U2 - https://doi.org/10.1097/JGP.0b013e3181aad5d7
DO - https://doi.org/10.1097/JGP.0b013e3181aad5d7
M3 - Article
C2 - 19625789
SN - 1064-7481
VL - 17
SP - 716
EP - 721
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 8
ER -