Leukocyte adhesion deficiencies

Edith van de Vijver; Timo K van den Berg; Taco W Kuijpers

doi:https://doi.org/10.1016/j.hoc.2012.10.001

Leukocyte adhesion deficiencies

Edith van de Vijver, Timo K van den Berg, Taco W Kuijpers

Research output: Contribution to journal › Review article › Academic › peer-review

96 Citations (Scopus)

Abstract

During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. Leukocyte adhesion deficiencies (ie, LAD-I, -II, and LAD-I/variant, the latter also known as LAD-III) are caused by defects in the adhesion of leukocytes to the vessel wall, resulting in severe recurrent nonpussing infections and neutrophilia, often preceded by delayed separation of the umbilical cord. Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment.

Original language	English
Pages (from-to)	101-16, viii
Journal	Hematology/oncology clinics of North America
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.hoc.2012.10.001
Publication status	Published - Feb 2013

Keywords

Congenital Disorders of Glycosylation
Humans
Leukocyte-Adhesion Deficiency Syndrome/complications
Prognosis

Access to Document

https://doi.org/10.1016/j.hoc.2012.10.001

Cite this

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title = "Leukocyte adhesion deficiencies",

abstract = "During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. Leukocyte adhesion deficiencies (ie, LAD-I, -II, and LAD-I/variant, the latter also known as LAD-III) are caused by defects in the adhesion of leukocytes to the vessel wall, resulting in severe recurrent nonpussing infections and neutrophilia, often preceded by delayed separation of the umbilical cord. Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment.",

keywords = "Congenital Disorders of Glycosylation, Humans, Leukocyte-Adhesion Deficiency Syndrome/complications, Prognosis",

author = "{van de Vijver}, Edith and {van den Berg}, {Timo K} and Kuijpers, {Taco W}",

year = "2013",

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doi = "https://doi.org/10.1016/j.hoc.2012.10.001",

language = "English",

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journal = "Hematology/oncology clinics of North America",

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T1 - Leukocyte adhesion deficiencies

AU - van de Vijver, Edith

AU - van den Berg, Timo K

AU - Kuijpers, Taco W

PY - 2013/2

Y1 - 2013/2

N2 - During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. Leukocyte adhesion deficiencies (ie, LAD-I, -II, and LAD-I/variant, the latter also known as LAD-III) are caused by defects in the adhesion of leukocytes to the vessel wall, resulting in severe recurrent nonpussing infections and neutrophilia, often preceded by delayed separation of the umbilical cord. Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment.

AB - During inflammation, leukocytes play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. Leukocyte adhesion deficiencies (ie, LAD-I, -II, and LAD-I/variant, the latter also known as LAD-III) are caused by defects in the adhesion of leukocytes to the vessel wall, resulting in severe recurrent nonpussing infections and neutrophilia, often preceded by delayed separation of the umbilical cord. Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment.

KW - Congenital Disorders of Glycosylation

KW - Humans

KW - Leukocyte-Adhesion Deficiency Syndrome/complications

KW - Prognosis

U2 - https://doi.org/10.1016/j.hoc.2012.10.001

DO - https://doi.org/10.1016/j.hoc.2012.10.001

M3 - Review article

C2 - 23351991

SN - 0889-8588

VL - 27

SP - 101-16, viii

JO - Hematology/oncology clinics of North America

JF - Hematology/oncology clinics of North America

IS - 1

ER -