Abstract
Original language | English |
---|---|
Article number | 109 |
Journal | Translational Psychiatry |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 2024 |
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In: Translational Psychiatry, Vol. 14, No. 1, 109, 01.12.2024.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks
T2 - a multi-omics replication study
AU - Ou, Anna H.
AU - Rosenthal, Sara B.
AU - Adli, Mazda
AU - Akiyama, Kazufumi
AU - Akula, Nirmala
AU - Alda, Martin
AU - Amare, Azmeraw T.
AU - Ardau, Raffaella
AU - Arias, B. rbara
AU - Aubry, Jean-Michel
AU - Backlund, Lena
AU - Bauer, Michael
AU - Baune, Bernhard T.
AU - Bellivier, Frank
AU - Benabarre, Antonio
AU - Bengesser, Susanne
AU - Bhattacharjee, Abesh Kumar
AU - Biernacka, Joanna M.
AU - Cervantes, Pablo
AU - Chen, Guo-Bo
AU - Chen, Hsi-Chung
AU - Chillotti, Caterina
AU - Cichon, Sven
AU - Clark, Scott R.
AU - Colom, Francesc
AU - Cousins, David A.
AU - Cruceanu, Cristiana
AU - Czerski, Piotr M.
AU - Dantas, Clarissa R.
AU - Dayer, Alexandre
AU - del Zompo, Maria
AU - Degenhardt, Franziska
AU - DePaulo, J. Raymond
AU - Étain, Bruno
AU - Falkai, Peter
AU - Fellendorf, Frederike Tabea
AU - Ferensztajn-Rochowiak, Ewa
AU - Forstner, Andreas J.
AU - Frisén, Louise
AU - Frye, Mark A.
AU - Fullerton, Janice M.
AU - Gard, S. bastien
AU - Garnham, Julie S.
AU - Goes, Fernando S.
AU - Grigoroiu-Serbanescu, Maria
AU - Grof, Paul
AU - Gruber, Oliver
AU - Hashimoto, Ryota
AU - Hauser, Joanna
AU - Heilbronner, Urs
AU - Herms, Stefan
AU - Hoffmann, Per
AU - Hofmann, Andrea
AU - Hou, Liping
AU - Jamain, Stephane
AU - Jiménez, Esther
AU - Kahn, Jean-Pierre
AU - Kassem, Layla
AU - Kato, Tadafumi
AU - Kittel-Schneider, Sarah
AU - König, Barbara
AU - Kuo, Po-Hsiu
AU - Kusumi, Ichiro
AU - Lackner, Nina
AU - Laje, Gonzalo
AU - Landén, Mikael
AU - Lavebratt, Catharina
AU - Leboyer, Marion
AU - Leckband, Susan G.
AU - Jaramillo, Carlos A. L. pez
AU - MacQueen, Glenda
AU - Maj, Mario
AU - Manchia, Mirko
AU - Marie-Claire, Cynthia
AU - Martinsson, Lina
AU - Mattheisen, Manuel
AU - McCarthy, Michael J.
AU - McElroy, Susan L.
AU - McMahon, Francis J.
AU - Mitchell, Philip B.
AU - Mitjans, Marina
AU - Mondimore, Francis M.
AU - Monteleone, Palmiero
AU - Nievergelt, Caroline M.
AU - Nöthen, Markus M.
AU - Novák, Tomas
AU - Ösby, Urban
AU - Ozaki, Norio
AU - Papiol, Sergi
AU - Perlis, Roy H.
AU - Pisanu, Claudia
AU - Potash, James B.
AU - Pfennig, Andrea
AU - Reich-Erkelenz, Daniela
AU - Reif, Andreas
AU - Reininghaus, Eva Z.
AU - Rietschel, Marcella
AU - Rouleau, Guy A.
AU - Rybakowski, Janusz K.
AU - Schalling, Martin
AU - Schofield, Peter R.
AU - Schubert, K. Oliver
AU - Schulze, Thomas G.
AU - Schweizer, Barbara W.
AU - Seemüller, Florian
AU - Severino, Giovanni
AU - Shekhtman, Tatyana
AU - Shilling, Paul D.
AU - Shimoda, Kazutaka
AU - Simhandl, Christian
AU - Slaney, Claire M.
AU - Squassina, Alessio
AU - Stamm, Thomas
AU - Stopkova, Pavla
AU - Tighe, Sarah K.
AU - Tortorella, Alfonso
AU - Turecki, Gustavo
AU - Vieta, Eduard
AU - Volkert, Julia
AU - Witt, Stephanie
AU - Wray, Naomi R.
AU - Wright, Adam
AU - Young, L. Trevor
AU - Zandi, Peter P.
AU - Kelsoe, John R.
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
AB - Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
UR - http://www.scopus.com/inward/record.url?scp=85185915765&partnerID=8YFLogxK
U2 - 10.1038/s41398-024-02811-4
DO - 10.1038/s41398-024-02811-4
M3 - Article
C2 - 38395906
SN - 2158-3188
VL - 14
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 109
ER -