TY - JOUR
T1 - Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy
AU - van Schie, Petra E. M.
AU - Schijns, Josephine
AU - Becher, Jules G.
AU - Barkhof, Frederik
AU - van Weissenbruch, Mirjam M.
AU - Vermeulen, R. Jeroen
PY - 2015
Y1 - 2015
N2 - Background: A cohort of children born with perinatal hypoxic-ischemic encephalopathy (HIE) was followed prospectively until school age. Aims: To describe motor outcome and behavioral functioning of school-age children after perinatal HIE and the relationship with neonatal MRI and outcome at age 2. Methods: Twenty-five children (19 males), born at term with perinatal HIE, were assessed at a mean age of 7 y 6 m (range 6 y 4 m-8 y 2 m). Motor ability was assessed with the Movement Assessment Battery for Children (2nd version) and behavioral functioning was assessed with the Child Behavior Checklist. Neonatal MRI was scored according to Barkovich classification. Results: Of the 25 included children, eight had cerebral palsy (CP). Of the 17 children without CP, nine had impaired motor ability (of which 3 scored definitely abnormal), and four had behavioral problems. There was a significant difference in motor performance (p = 0.008) between children with normal and children with abnormal neonatal MRI. Two (of four) children with normal motor ability and seven (of 14) children with normal neurological examination at age 2 showed impaired motor ability at school age. Conclusions: Half of the children without CP had impaired motor ability at school age. A normal outcome after HIE at young age does not necessarily imply a good outcome at school age, even when neonatal MRI does not show any abnormalities. More research is needed on the behavioral and cognitive consequences of HIE at school age and on the consequences for quality of life for children with and without CP. (C) 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved
AB - Background: A cohort of children born with perinatal hypoxic-ischemic encephalopathy (HIE) was followed prospectively until school age. Aims: To describe motor outcome and behavioral functioning of school-age children after perinatal HIE and the relationship with neonatal MRI and outcome at age 2. Methods: Twenty-five children (19 males), born at term with perinatal HIE, were assessed at a mean age of 7 y 6 m (range 6 y 4 m-8 y 2 m). Motor ability was assessed with the Movement Assessment Battery for Children (2nd version) and behavioral functioning was assessed with the Child Behavior Checklist. Neonatal MRI was scored according to Barkovich classification. Results: Of the 25 included children, eight had cerebral palsy (CP). Of the 17 children without CP, nine had impaired motor ability (of which 3 scored definitely abnormal), and four had behavioral problems. There was a significant difference in motor performance (p = 0.008) between children with normal and children with abnormal neonatal MRI. Two (of four) children with normal motor ability and seven (of 14) children with normal neurological examination at age 2 showed impaired motor ability at school age. Conclusions: Half of the children without CP had impaired motor ability at school age. A normal outcome after HIE at young age does not necessarily imply a good outcome at school age, even when neonatal MRI does not show any abnormalities. More research is needed on the behavioral and cognitive consequences of HIE at school age and on the consequences for quality of life for children with and without CP. (C) 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.ejpn.2015.01.005
DO - https://doi.org/10.1016/j.ejpn.2015.01.005
M3 - Article
C2 - 25683783
SN - 1090-3798
VL - 19
SP - 354
EP - 359
JO - European journal of paediatric neurology : EJPN
JF - European journal of paediatric neurology : EJPN
IS - 3
ER -