TY - JOUR
T1 - Longitudinal changes of CSF biomarkers in memory clinic patients
AU - Bouwman, F. H.
AU - Van Der Flier, W. M.
AU - Schoonenboom, N. S.M.
AU - Van Elk, E. J.
AU - Kok, A.
AU - Rijmen, F.
AU - Blankenstein, M. A.
AU - Scheltens, P.
PY - 2007/9/1
Y1 - 2007/9/1
N2 - OBJECTIVE: In Alzheimer disease (AD), longitudinal changes of beta-amyloid1-42 (Aβ1-42), tau, and phosphorylated tau at threonine 181 (ptau-181) in CSF have been reported in small studies only. We evaluated the natural course of CSF biomarkers in patients with AD, subjective complaints, and mild cognitive impairment (MCI). METHODS: One hundred five patients (50 AD, 38 MCI, 17 subjective complaints) underwent two lumbar punctures, with a mean interval of 21 ± 9 months. CSF levels of Aβ1-42, tau, and ptau-181 were measured. RESULTS: CSF Aβ1-42 and tau levels showed main effects for both diagnosis and time (all p < 0.05), with average increases of 47 ± 72 and 49 ± 143 pg/mL. The interaction terms were not significant, which implies a similar time effect for all diagnostic groups. CSF ptau-181 levels showed a main effect for diagnosis (p = 0.01) but not for time (p = 0.27, increase of 1.0 ± 12 pg/mL). CONCLUSION: Levels of CSF beta-amyloid1-42 and tau but not phosphorylated tau at threonine 181 increased over time in this memory clinic patient cohort with comparable change in all diagnostic groups. The cross-sectional difference between diagnostic groups, however, exceeded by far the longitudinal changes within individuals, suggesting that these biomarkers are not sensitive as markers of disease progression.
AB - OBJECTIVE: In Alzheimer disease (AD), longitudinal changes of beta-amyloid1-42 (Aβ1-42), tau, and phosphorylated tau at threonine 181 (ptau-181) in CSF have been reported in small studies only. We evaluated the natural course of CSF biomarkers in patients with AD, subjective complaints, and mild cognitive impairment (MCI). METHODS: One hundred five patients (50 AD, 38 MCI, 17 subjective complaints) underwent two lumbar punctures, with a mean interval of 21 ± 9 months. CSF levels of Aβ1-42, tau, and ptau-181 were measured. RESULTS: CSF Aβ1-42 and tau levels showed main effects for both diagnosis and time (all p < 0.05), with average increases of 47 ± 72 and 49 ± 143 pg/mL. The interaction terms were not significant, which implies a similar time effect for all diagnostic groups. CSF ptau-181 levels showed a main effect for diagnosis (p = 0.01) but not for time (p = 0.27, increase of 1.0 ± 12 pg/mL). CONCLUSION: Levels of CSF beta-amyloid1-42 and tau but not phosphorylated tau at threonine 181 increased over time in this memory clinic patient cohort with comparable change in all diagnostic groups. The cross-sectional difference between diagnostic groups, however, exceeded by far the longitudinal changes within individuals, suggesting that these biomarkers are not sensitive as markers of disease progression.
UR - http://www.scopus.com/inward/record.url?scp=34548450659&partnerID=8YFLogxK
U2 - https://doi.org/10.1212/01.wnl.0000271375.37131.04
DO - https://doi.org/10.1212/01.wnl.0000271375.37131.04
M3 - Article
C2 - 17785669
SN - 0028-3878
VL - 69
SP - 1006
EP - 1011
JO - Neurology
JF - Neurology
IS - 10
ER -