Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination

Marleen van Dijk; Joost P. H. Drenth; Joop E. Arends; Sylvia M. Brakenhoff; Cas J. Isfordink; Rob de Knegt; Marc van der Valk

doi:https://doi.org/10.1111/jvh.13399

Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination

Marleen van Dijk, Joost P. H. Drenth, Joop E. Arends, Sylvia M. Brakenhoff, Cas J. Isfordink, Rob de Knegt, Marc van der Valk

Research output: Contribution to journal › Review article › Academic › peer-review

22 Citations (Scopus)

Abstract

Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the Netherlands. Micro-elimination through retrieval can contribute to reaching the World Health Organization's viral hepatitis elimination targets by 2030.

Original language	English
Pages (from-to)	1270-1283
Number of pages	14
Journal	Journal of viral hepatitis
Volume	27
Issue number	12
Early online date	2020
DOIs	https://doi.org/10.1111/jvh.13399
Publication status	Published - 1 Dec 2020

Keywords

cascade of care
hepatitis C
lost to follow-up
micro-elimination

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Cite this

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title = "Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination",

abstract = "Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the Netherlands. Micro-elimination through retrieval can contribute to reaching the World Health Organization's viral hepatitis elimination targets by 2030.",

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AU - van Dijk, Marleen

AU - Drenth, Joost P. H.

AU - Arends, Joop E.

AU - Brakenhoff, Sylvia M.

AU - Isfordink, Cas J.

AU - de Knegt, Rob

AU - van der Valk, Marc

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AB - Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the Netherlands. Micro-elimination through retrieval can contribute to reaching the World Health Organization's viral hepatitis elimination targets by 2030.

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Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination

Abstract

Keywords

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