Abstract
Bacterial meningitis is a complex disorder in which injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal meningitis. Here, we discuss the role of MIF in infection, the brain, and corticosteroids and conclude that experimental meningitis studies have to determine whether MIF is a potential target for adjunctive therapy in pneumococcal meningitis
Original language | Undefined/Unknown |
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Pages (from-to) | 170 |
Journal | Critical Care |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2009 |