TY - JOUR
T1 - Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group
T2 - Findings from the ENIGMA Addiction Working Group
AU - Cao, Zhipeng
AU - Ottino-Gonzalez, Jonatan
AU - Cupertino, Renata B.
AU - Schwab, Nathan
AU - Hoke, Colin
AU - Catherine, Orr
AU - Cousijn, Janna
AU - Dagher, Alain
AU - Foxe, John J.
AU - Goudriaan, Anna E.
AU - Hester, Robert
AU - Hutchison, Kent
AU - Li, Chiang-Shan R.
AU - London, Edythe D.
AU - Lorenzetti, Valentina
AU - Luijten, Maartje
AU - Martin-Santos, Rocio
AU - Momenan, Reza
AU - Paulus, Martin P.
AU - Schmaal, Lianne
AU - Sinha, Rajita
AU - Sjoerds, Zsuzsika
AU - Solowij, Nadia
AU - Stein, Dan J.
AU - Stein, Elliot A.
AU - Uhlmann, Anne
AU - van Holst, Ruth J.
AU - Veltman, Dick J.
AU - Wiers, Reinout W.
AU - Yücel, Murat
AU - Zhang, Sheng
AU - Jahanshad, Neda
AU - Thompson, Paul M.
AU - Conrod, Patricia
AU - Mackey, Scott
AU - Garavan, Hugh
N1 - Funding Information: Z.C., J.O., R.B.C., N.C., and S.M. received support by NIDA grant R01DA047119, awarded to P.C. and H.G. R.W.W. received support for the Neuro-ADAPT study from VICI grant 453.08.01 from the Netherlands Organization for Scientific Research (NWO). L.S. and D.V. received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160003 from NWO. N.S. and D.V. received funding from ZonMW grant 31160004 from NWO. A.E.G. and R.J.H. received funding from ZonMW grant 91676084 from NWO. M.L. and D.V. received funding from VIDI grant 016.08.322 from NWO, awarded to Ingmar H.?A. Franken. J.C. and A.E.G. received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. H.G. and J.F. received funds from NIDA grant R01-DA014100. C.R.L. received funding from NIH grants R01AA021449, R01DA023248, R21DA044749, and R21DA045189. S.Z. received funding from NIDA grant K25DA040032. E.L. was supported by NIDA grant R01 DA020726, the Thomas P. and Katherine K. Pike Chair in Addiction Studies, the Endowment from the Marjorie Greene Family Trust, and UCLA contract 20063287 with Philip Morris, USA. Data collection by R.M. was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). M.P.P. received funding from NIMH grant R01 DA018307. A.S. was supported by the Intramural Research Program of NIDA and NIH. R.S. received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). N.S. received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. M.Y. was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. P.T. was supported by NIH grants U54 EB020403 from the Big Data to Knowledge (BD2K) program, R01 MH116147, P41 EB015922, and R01 MH111671. N.J. was supported by NIH grants R01MH117601, R01AG059874, R01MH121246, P41EB015922, and R01MH116147. Publisher Copyright: © 2021 Society for the Study of Addiction Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega-analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis (n = 1,796) and nondependent participants (n = 996). Substance-general and substance-specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's d = 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's d = 0.10) and nicotine dependence (less rightward; Cohen's d = 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.
AB - Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega-analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis (n = 1,796) and nondependent participants (n = 996). Substance-general and substance-specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's d = 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's d = 0.10) and nicotine dependence (less rightward; Cohen's d = 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.
KW - brain asymmetry
KW - mega-analysis
KW - substance dependence
UR - http://www.scopus.com/inward/record.url?scp=85099801261&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/63522404/adb13010_sup_0001_data_s1.docx
U2 - https://doi.org/10.1111/adb.13010
DO - https://doi.org/10.1111/adb.13010
M3 - Article
C2 - 33508888
SN - 1355-6215
VL - 26
JO - Addiction Biology
JF - Addiction Biology
IS - 5
M1 - e13010
ER -