TY - JOUR
T1 - Menage a trois: Borrelia, dendritic cells, and tick saliva interactions
AU - Mason, Lauren M. K.
AU - Veerman, Christiaan C.
AU - Geijtenbeek, Teunis B. H.
AU - Hovius, Joppe W. R.
PY - 2014
Y1 - 2014
N2 - Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, is inoculated into the skin during an lxodes tick bite where it is recognised and captured by dendritic cells (DCs). However, considering the propensity of Borrelia to disseminate, it would appear that DCs fall short in mounting a robust immune response against it. Many aspects of the DC-driven immune response to Borrelia have been examined. Recently, components of tick saliva have been identified that sabotage DC responses and aid Borrelia infection. In this review, we summarise what is currently known about the immune response of DCs to Borrelia and explore the mechanisms by which Borrelia manages to circumvent this immune response, with or without the help of tick salivary proteins
AB - Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, is inoculated into the skin during an lxodes tick bite where it is recognised and captured by dendritic cells (DCs). However, considering the propensity of Borrelia to disseminate, it would appear that DCs fall short in mounting a robust immune response against it. Many aspects of the DC-driven immune response to Borrelia have been examined. Recently, components of tick saliva have been identified that sabotage DC responses and aid Borrelia infection. In this review, we summarise what is currently known about the immune response of DCs to Borrelia and explore the mechanisms by which Borrelia manages to circumvent this immune response, with or without the help of tick salivary proteins
U2 - https://doi.org/10.1016/j.pt.2013.12.003
DO - https://doi.org/10.1016/j.pt.2013.12.003
M3 - Review article
C2 - 24388562
SN - 1471-4922
VL - 30
SP - 95
EP - 103
JO - Trends in parasitology
JF - Trends in parasitology
IS - 2
ER -