Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis.

J.R. Piet; P. van Ulsen; S. Ur Rahman; S. Bovenkerk; S.D. Bentley; S. van de Beek; A. van der Ende; Diederik van de Beek

doi:https://doi.org/10.1128/IAI.00160-16

Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis.

J.R. Piet, P. van Ulsen, S. Ur Rahman, S. Bovenkerk, S.D. Bentley, S. van de Beek, A. van der Ende, Diederik van de Beek

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We evaluated the distribution of TPS systems among clinical isolates from two prospective cohort studies comprising 373 patients with meningococcal meningitis. TPS system 1 was present in 91% of isolates, and system 2 and/or 3 was present in 67%. The TPS system distribution was related to clonal complexes. Infection with strains with TPS2 and/or TPS3 resulted in less severe disease and better outcomes than infection with strains without these systems. Using whole-blood stimulation experiments, we found no differences in the host cytokine response between patients infected with TPS system 2 and 3 knockout strains and patients infected with a wild-type strain. In conclusion, meningococcal TPS system 2 and/or 3 is associated with disease severity and outcome in patients with meningitis

Original language	Undefined/Unknown
Pages (from-to)	2534-2540
Journal	Infection and immunity
Volume	84
Issue number	9
DOIs	https://doi.org/10.1128/IAI.00160-16
Publication status	Published - 2016

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https://doi.org/10.1128/IAI.00160-16

http://dx.doi.org/10.1128/iai.00160-16

Cite this

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title = "Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis.",

abstract = "Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We evaluated the distribution of TPS systems among clinical isolates from two prospective cohort studies comprising 373 patients with meningococcal meningitis. TPS system 1 was present in 91% of isolates, and system 2 and/or 3 was present in 67%. The TPS system distribution was related to clonal complexes. Infection with strains with TPS2 and/or TPS3 resulted in less severe disease and better outcomes than infection with strains without these systems. Using whole-blood stimulation experiments, we found no differences in the host cytokine response between patients infected with TPS system 2 and 3 knockout strains and patients infected with a wild-type strain. In conclusion, meningococcal TPS system 2 and/or 3 is associated with disease severity and outcome in patients with meningitis",

author = "J.R. Piet and {van Ulsen}, P. and {Ur Rahman}, S. and S. Bovenkerk and S.D. Bentley and {van de Beek}, S. and {van der Ende}, A. and {van de Beek}, Diederik",

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T1 - Meningococcal two-partner secretion systems and their association with outcome in patients with meningitis.

AU - Piet, J.R.

AU - van Ulsen, P.

AU - Ur Rahman, S.

AU - Bovenkerk, S.

AU - Bentley, S.D.

AU - van de Beek, S.

AU - van der Ende, A.

AU - van de Beek, Diederik

PY - 2016

Y1 - 2016

N2 - Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We evaluated the distribution of TPS systems among clinical isolates from two prospective cohort studies comprising 373 patients with meningococcal meningitis. TPS system 1 was present in 91% of isolates, and system 2 and/or 3 was present in 67%. The TPS system distribution was related to clonal complexes. Infection with strains with TPS2 and/or TPS3 resulted in less severe disease and better outcomes than infection with strains without these systems. Using whole-blood stimulation experiments, we found no differences in the host cytokine response between patients infected with TPS system 2 and 3 knockout strains and patients infected with a wild-type strain. In conclusion, meningococcal TPS system 2 and/or 3 is associated with disease severity and outcome in patients with meningitis

AB - Two-partner secretion (TPS) systems export large TpsA proteins to the surface and extracellular milieu. In meningococci, three different TPS systems exist, and of these, TPS system 2 (TPS2) and TPS3 can be detected by the host's immune system. We evaluated the distribution of TPS systems among clinical isolates from two prospective cohort studies comprising 373 patients with meningococcal meningitis. TPS system 1 was present in 91% of isolates, and system 2 and/or 3 was present in 67%. The TPS system distribution was related to clonal complexes. Infection with strains with TPS2 and/or TPS3 resulted in less severe disease and better outcomes than infection with strains without these systems. Using whole-blood stimulation experiments, we found no differences in the host cytokine response between patients infected with TPS system 2 and 3 knockout strains and patients infected with a wild-type strain. In conclusion, meningococcal TPS system 2 and/or 3 is associated with disease severity and outcome in patients with meningitis

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DO - https://doi.org/10.1128/IAI.00160-16

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