TY - JOUR
T1 - Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life
AU - Natama, Hamtandi Magloire
AU - Moncunill, Gemma
AU - Rovira-Vallbona, Eduard
AU - Sanz, H. ctor
AU - Sorgho, Hermann
AU - Aguilar, Ruth
AU - Coulibaly-Traoré, Maminata
AU - Somé, M. Athanase
AU - Scott, Susana
AU - Valéa, Innocent
AU - Mens, Petra F.
AU - Schallig, Henk D. F. H.
AU - Kestens, Luc
AU - Tinto, Halidou
AU - Dobaño, Carlota
AU - Rosanas-Urgell, Anna
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we examined the impact of four types of PME (i.e., maternal peripheral infection and placental acute, chronic, and past infections) on both spontaneous and toll-like receptors (TLRs)-mediated cytokine production in cord blood and how these innate immune responses modulate the risk of malaria during the first year of life.
AB - BACKGROUND: Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we examined the impact of four types of PME (i.e., maternal peripheral infection and placental acute, chronic, and past infections) on both spontaneous and toll-like receptors (TLRs)-mediated cytokine production in cord blood and how these innate immune responses modulate the risk of malaria during the first year of life.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055913515&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30384846
U2 - https://doi.org/10.1186/s12916-018-1187-3
DO - https://doi.org/10.1186/s12916-018-1187-3
M3 - Article
C2 - 30384846
SN - 1464-2662
VL - 16
SP - 198
JO - BMC medicine
JF - BMC medicine
IS - 1
ER -