Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

Mark C. Dessing; Alex F. de Vos; Sandrine Florquin; Tom van der Poll

doi:https://doi.org/10.1128/IAI.00977-06

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

Mark C. Dessing, Alex F. de Vos, Sandrine Florquin, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality

Original language	English
Pages (from-to)	7021-7023
Journal	Infection and immunity
Volume	74
Issue number	12
DOIs	https://doi.org/10.1128/IAI.00977-06
Publication status	Published - 2006

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https://doi.org/10.1128/IAI.00977-06

Cite this

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title = "Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia",

abstract = "To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality",

author = "Dessing, {Mark C.} and {de Vos}, {Alex F.} and Sandrine Florquin and {van der Poll}, Tom",

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AU - van der Poll, Tom

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AB - To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality

U2 - https://doi.org/10.1128/IAI.00977-06

DO - https://doi.org/10.1128/IAI.00977-06

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