Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG

Keith S Cover; Hugo Vrenken; Jeroen J G Geurts; Bob W van Oosten; Brechtje Jelles; Chris H Polman; Cornelis J Stam

doi:https://doi.org/10.1016/j.neuroimage.2005.08.048

Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG

Keith S Cover, Hugo Vrenken, Jeroen J G Geurts, Bob W van Oosten, Brechtje Jelles, Chris H Polman, Cornelis J Stam

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Scopus)

Abstract

MEG data were acquired from a group of relapsing-remitting multiple sclerosis (MS) patients and a group of healthy controls, using an eyes-closed no-task condition. An interhemispheric coherence measure (IHCM), reflecting the synchronization between the left and right hemispheres, showed a decrease in the patients, particularly in the alpha band. No comparable differences were seen in the alpha band power or its distribution over the head. The observed difference is in agreement with a reduced long-range connectivity in the brains of MS patients. The IHCM was found to be reproducible in controls over a period of more than 15 months. Further studies should investigate whether MEG derived synchronization measures may be useful as markers for MS disease load.

Original language	English
Pages (from-to)	783-8
Number of pages	6
Journal	NEUROIMAGE
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroimage.2005.08.048
Publication status	Published - 1 Feb 2006

Keywords

Adult
Alpha Rhythm
Brain Mapping
Cortical Synchronization
Data Interpretation, Statistical
Disability Evaluation
Female
Functional Laterality/physiology
Humans
Magnetoencephalography
Male
Middle Aged
Multiple Sclerosis/physiopathology
Reproducibility of Results

Access to Document

https://doi.org/10.1016/j.neuroimage.2005.08.048

Cite this

@article{ba3b3272d4d64a38a0857b02a5521ad2,

title = "Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG",

abstract = "MEG data were acquired from a group of relapsing-remitting multiple sclerosis (MS) patients and a group of healthy controls, using an eyes-closed no-task condition. An interhemispheric coherence measure (IHCM), reflecting the synchronization between the left and right hemispheres, showed a decrease in the patients, particularly in the alpha band. No comparable differences were seen in the alpha band power or its distribution over the head. The observed difference is in agreement with a reduced long-range connectivity in the brains of MS patients. The IHCM was found to be reproducible in controls over a period of more than 15 months. Further studies should investigate whether MEG derived synchronization measures may be useful as markers for MS disease load.",

keywords = "Adult, Alpha Rhythm, Brain Mapping, Cortical Synchronization, Data Interpretation, Statistical, Disability Evaluation, Female, Functional Laterality/physiology, Humans, Magnetoencephalography, Male, Middle Aged, Multiple Sclerosis/physiopathology, Reproducibility of Results",

author = "Cover, {Keith S} and Hugo Vrenken and Geurts, {Jeroen J G} and {van Oosten}, {Bob W} and Brechtje Jelles and Polman, {Chris H} and Stam, {Cornelis J}",

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T1 - Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG

AU - Cover, Keith S

AU - Vrenken, Hugo

AU - Geurts, Jeroen J G

AU - van Oosten, Bob W

AU - Jelles, Brechtje

AU - Polman, Chris H

AU - Stam, Cornelis J

PY - 2006/2/1

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AB - MEG data were acquired from a group of relapsing-remitting multiple sclerosis (MS) patients and a group of healthy controls, using an eyes-closed no-task condition. An interhemispheric coherence measure (IHCM), reflecting the synchronization between the left and right hemispheres, showed a decrease in the patients, particularly in the alpha band. No comparable differences were seen in the alpha band power or its distribution over the head. The observed difference is in agreement with a reduced long-range connectivity in the brains of MS patients. The IHCM was found to be reproducible in controls over a period of more than 15 months. Further studies should investigate whether MEG derived synchronization measures may be useful as markers for MS disease load.

KW - Adult

KW - Alpha Rhythm

KW - Brain Mapping

KW - Cortical Synchronization

KW - Data Interpretation, Statistical

KW - Disability Evaluation

KW - Female

KW - Functional Laterality/physiology

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/physiopathology

KW - Reproducibility of Results

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DO - https://doi.org/10.1016/j.neuroimage.2005.08.048

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SN - 1053-8119

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