TY - JOUR
T1 - Natural infection as a blueprint for rational HIV vaccine design
AU - van Haaren, Marlies M.
AU - van den Kerkhof, Tom L. G. M.
AU - van Gils, Marit J.
PY - 2017
Y1 - 2017
N2 - So far, the development of a human immunodeficiency virus (HIV) vaccine has been unsuccessful. However, recent progress in the field of broadly neutralizing antibodies (bNAbs) has reinvigorated the search for an HIV vaccine. bNAbs develop in a minority of HIV infected individuals and passive transfer of these bNAbs to non-human primates provides protection from HIV infection. Studies in a number of HIV infected individuals on bNAb maturation alongside viral evolution and escape have shed light on the features important for bNAb elicitation. Here we review the observations from these studies, and how they influence the rational design of HIV vaccines
AB - So far, the development of a human immunodeficiency virus (HIV) vaccine has been unsuccessful. However, recent progress in the field of broadly neutralizing antibodies (bNAbs) has reinvigorated the search for an HIV vaccine. bNAbs develop in a minority of HIV infected individuals and passive transfer of these bNAbs to non-human primates provides protection from HIV infection. Studies in a number of HIV infected individuals on bNAb maturation alongside viral evolution and escape have shed light on the features important for bNAb elicitation. Here we review the observations from these studies, and how they influence the rational design of HIV vaccines
U2 - https://doi.org/10.1080/21645515.2016.1232785
DO - https://doi.org/10.1080/21645515.2016.1232785
M3 - Review article
C2 - 27649455
SN - 2164-5515
VL - 13
SP - 229
EP - 236
JO - Human vaccines & immunotherapeutics
JF - Human vaccines & immunotherapeutics
IS - 1
ER -