TY - JOUR
T1 - Neuronal regulation of intestinal immune functions in health and disease
AU - Fornai, M.
AU - van den Wijngaard, R. M.
AU - Antonioli, L.
AU - Pellegrini, C.
AU - Blandizzi, C.
AU - de Jonge, W. J.
PY - 2018
Y1 - 2018
N2 - Background: Nerve-mucosa interactions control various elements of gastrointestinal functions, including mucosal host defense, gut barrier function, and epithelial cell growth and differentiation. In both intestinal and extra-intestinal diseases, alterations of autonomic nerve activity have been observed to be concurrent with the disease course, such as in inflammatory and functional bowel diseases, and neurodegenerative diseases. This is relevant as the extrinsic autonomic nervous system is increasingly recognized to modulate gut inflammatory responses. The molecular and cellular mechanisms through which the extrinsic and intrinsic nerve pathways may regulate digestive mucosal functions have been investigated in several pre-clinical and clinical studies. Purpose: The present review focuses on the involvement of neural pathways in gastrointestinal disease, and addresses the current strategies to intervene with neuronal pathway as a means of treatment.
AB - Background: Nerve-mucosa interactions control various elements of gastrointestinal functions, including mucosal host defense, gut barrier function, and epithelial cell growth and differentiation. In both intestinal and extra-intestinal diseases, alterations of autonomic nerve activity have been observed to be concurrent with the disease course, such as in inflammatory and functional bowel diseases, and neurodegenerative diseases. This is relevant as the extrinsic autonomic nervous system is increasingly recognized to modulate gut inflammatory responses. The molecular and cellular mechanisms through which the extrinsic and intrinsic nerve pathways may regulate digestive mucosal functions have been investigated in several pre-clinical and clinical studies. Purpose: The present review focuses on the involvement of neural pathways in gastrointestinal disease, and addresses the current strategies to intervene with neuronal pathway as a means of treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051017213&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30058092
U2 - https://doi.org/10.1111/nmo.13406
DO - https://doi.org/10.1111/nmo.13406
M3 - Article
C2 - 30058092
SN - 1350-1925
VL - 30
SP - e13406
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 12
ER -