Neutropenie door antistoffen tegen Fc-receptoren type III op neutrofiele granulocyten: 3 hinderen met verschillend ziektebeloop

Three children (girls) suffered from neutropenia mediated by anti-neutrophil IgG-Fc receptor type III (FcyRIII) antibodies. The first patient (newborn) had asymptomatic and transient neutropenia caused by maternal FcyRIII iso-antibodies. The second patient (6 months), whose neutropenia was diagnosed as a 'benign neutropenia of childhood' caused by transient anti-NAi autoantibodies, suffered from mild bacterial infections. The third patient (12 years) suffered from serious infections. The anti-FcyRIII autoantibodies showed neither anti-NAi nor anti-NAi specificity. She also developed autoimmune thyroiditis (Graves' disease). Both the duration of the neutropcnia and the seriousness of the bacterial infection were variable in our patient group. The first two patients both made spontaneous recoveries, while the third patient depended ultimately on granulocyte-colony stimulating factor (G-CSF).