TY - JOUR
T1 - Normal gyration and sulcation in preterm and term neonates
T2 - Appearance on MR images
AU - Van Der Knaap, Marjo S.
AU - Van Wezel-Meijler, Gerda
AU - Barth, Peter G.
AU - Barkhof, Frederik
AU - Adèr, Herman J.
AU - Valk, Jaap
PY - 1996/8
Y1 - 1996/8
N2 - PURPOSE: To provide a practical standard for normal development of gyri and sulci in preterm and term neonates. MATERIALS AND METHODS: Thirty-nine living preterm infants without substantial neurologic problems underwent magnetic resonance (MR) imaging of the brain. Five infants who were born at term but died of a nonneurologic disorder within 1 week and who underwent autopsy were examined after death with MR imaging. Seven cerebral surface areas were defined, and the development of gyri and sulci in each area was assigned a score between 1 and 5. RESULTS: The postconceptional age (PCA) range of the newborns was 30-42 weeks. When the gyral development scores were assessed as a function of PCA, four transition points could be discerned for the brain as a whole; these transitions occurred at PCAs of 32, 34, 37, and 40 1/4 -41 weeks. These four transition points allowed the general gyral development to be divided into five stages. Development of gyri and sulci was most advanced in the area of the central sulcus and the medial occipital area. Development was latest in the frontobasal and frontopolar areas and the anterior part of the temporal lobe. CONCLUSION: A simple staging system allows easy assessment of the progress of cerebral gyration and sulcation in preterm and term infants.
AB - PURPOSE: To provide a practical standard for normal development of gyri and sulci in preterm and term neonates. MATERIALS AND METHODS: Thirty-nine living preterm infants without substantial neurologic problems underwent magnetic resonance (MR) imaging of the brain. Five infants who were born at term but died of a nonneurologic disorder within 1 week and who underwent autopsy were examined after death with MR imaging. Seven cerebral surface areas were defined, and the development of gyri and sulci in each area was assigned a score between 1 and 5. RESULTS: The postconceptional age (PCA) range of the newborns was 30-42 weeks. When the gyral development scores were assessed as a function of PCA, four transition points could be discerned for the brain as a whole; these transitions occurred at PCAs of 32, 34, 37, and 40 1/4 -41 weeks. These four transition points allowed the general gyral development to be divided into five stages. Development of gyri and sulci was most advanced in the area of the central sulcus and the medial occipital area. Development was latest in the frontobasal and frontopolar areas and the anterior part of the temporal lobe. CONCLUSION: A simple staging system allows easy assessment of the progress of cerebral gyration and sulcation in preterm and term infants.
KW - Brain, MR
KW - Brain, growth and development
KW - Infants, newborn, central nervous system
KW - Magnetic resonance (MR), in infants and children
UR - http://www.scopus.com/inward/record.url?scp=0029992752&partnerID=8YFLogxK
U2 - https://doi.org/10.1148/radiology.200.2.8685331
DO - https://doi.org/10.1148/radiology.200.2.8685331
M3 - Article
C2 - 8685331
SN - 0033-8419
VL - 200
SP - 389
EP - 396
JO - Radiology
JF - Radiology
IS - 2
ER -