Novel Insights into Membrane Targeting of B Cell Lymphoma

Charlotte M. de Winde, Suraya Elfrink, Annemiek B. van Spriel

Research output: Contribution to journalReview articleAcademicpeer-review

21 Citations (Scopus)


Standard therapy of patients with B cell non-Hodgkin lymphoma (B-NHL) predominantly consists of chemotherapy combined with anti-CD20 (e.g., rituximab) immunotherapy. However, relapse of aggressive B-NHL occurs frequently, and this may coincide with therapy resistance. This demonstrates the urgent need for exploring new lymphoma-targeted therapies. We review here recent insights in the pathophysiology of B-NHL and discuss CD20 and three alternative membrane targets (B cell receptor, immune checkpoints PD-1/PD-L1, tetraspanin CD37) that are currently in the spotlight for B-NHL treatment. Furthermore, we present a novel concept in which the plasma membrane organization of the lymphoma B cell determines the efficacy of membrane-targeted therapies, and this has consequences for treatment application and clinical outcome in patients with B cell lymphoma.

Original languageEnglish
Pages (from-to)442-453
Number of pages12
JournalTrends in Cancer
Issue number6
Publication statusPublished - Jun 2017
Externally publishedYes


  • B cell
  • immunotherapy
  • membrane organization
  • membrane target
  • non-Hodgkin lymphoma

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