TY - JOUR
T1 - Nuclear receptor Nur77
T2 - Its role in chronic inflammatory diseases
AU - Lith, Sanne C.
AU - de Vries, Carlie J. M.
N1 - Funding Information: This work is financed by the Ministry of Economic Affairs by means of the Private-Public-Partnership Allowance made available by the Top Sector Life Sciences & Health to stimulate public-private Partnerships and by funding of Amsterdam UMC (to CJMdV). Publisher Copyright: © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells and is differentially expressed in chronically inflamed organs in human and experimental models. Furthermore, in a variety of animal models dedicated to study inflammatory diseases, changes in Nur77 expression alter disease outcome. The available studies comprise a wealth of information on the function of Nur77 in diverse cell types and tissues. Negative cross-talk of Nur77 with the NFκB signaling complex is an example of Nur77 effector function. An alternative mechanism of action has been established, involving Nur77-mediated modulation of metabolism in macrophages as well as in T cells. In this review, we summarize our current knowledge on the role of Nur77 in atherosclerosis, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and sepsis. Detailed insight in the control of inflammatory responses will be essential in order to advance Nur77-targeted therapeutic interventions in inflammatory disease.
AB - Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells and is differentially expressed in chronically inflamed organs in human and experimental models. Furthermore, in a variety of animal models dedicated to study inflammatory diseases, changes in Nur77 expression alter disease outcome. The available studies comprise a wealth of information on the function of Nur77 in diverse cell types and tissues. Negative cross-talk of Nur77 with the NFκB signaling complex is an example of Nur77 effector function. An alternative mechanism of action has been established, involving Nur77-mediated modulation of metabolism in macrophages as well as in T cells. In this review, we summarize our current knowledge on the role of Nur77 in atherosclerosis, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and sepsis. Detailed insight in the control of inflammatory responses will be essential in order to advance Nur77-targeted therapeutic interventions in inflammatory disease.
UR - http://www.scopus.com/inward/record.url?scp=85120946973&partnerID=8YFLogxK
U2 - https://doi.org/10.1042/EBC20210004
DO - https://doi.org/10.1042/EBC20210004
M3 - Review article
C2 - 34328179
SN - 0071-1365
VL - 65
SP - 927
EP - 939
JO - Essays in biochemistry
JF - Essays in biochemistry
IS - 6
ER -