TY - CHAP
T1 - Obesity
T2 - An addiction? Imaging of neurotransmitter systems in obesity
AU - van de Giessen, Elsmarieke
AU - McIlwrick, Silja
AU - Veltman, Dick
AU - van den Brink, Wim
AU - Booij, Jan
PY - 2020/12/14
Y1 - 2020/12/14
N2 - The brain is important in the regulation of eating behavior and satiety signaling. There is also evidence that many neurotransmitters are involved in food intake regulation and eating behavior; consequently dysregulated neurotransmitter systems may be involved in the pathophysiology of obesity. This chapter presents an overview of results of neurotransmitter imaging studies in obese humans. Presently, the dopaminergic, serotonergic, noradrenergic, opioid and cannabinoid systems have been studied with molecular imaging techniques in obese humans. The major findings are increased serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptor availability in cortical regions, a complex relationship between dopamine D2/3 receptor (DRD2/3) availability and body mass index (BMI), probably an important role of the striatal and extra-striatal mu opioid receptor, and a possible role of the cannabinoid type 1 (CB1) receptor. There is no disturbance in serotonin transporter (SERT) availability in the thalamus and midbrain or in striatal dopamine transporter (DAT) availability. The effects of bariatric surgery on neurotransmission and findings in subgroups such as patients with binge eating disorder or insulin resistance are also discussed.
AB - The brain is important in the regulation of eating behavior and satiety signaling. There is also evidence that many neurotransmitters are involved in food intake regulation and eating behavior; consequently dysregulated neurotransmitter systems may be involved in the pathophysiology of obesity. This chapter presents an overview of results of neurotransmitter imaging studies in obese humans. Presently, the dopaminergic, serotonergic, noradrenergic, opioid and cannabinoid systems have been studied with molecular imaging techniques in obese humans. The major findings are increased serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptor availability in cortical regions, a complex relationship between dopamine D2/3 receptor (DRD2/3) availability and body mass index (BMI), probably an important role of the striatal and extra-striatal mu opioid receptor, and a possible role of the cannabinoid type 1 (CB1) receptor. There is no disturbance in serotonin transporter (SERT) availability in the thalamus and midbrain or in striatal dopamine transporter (DAT) availability. The effects of bariatric surgery on neurotransmission and findings in subgroups such as patients with binge eating disorder or insulin resistance are also discussed.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149308524&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36876289
U2 - https://doi.org/10.1007/978-3-030-57231-0_26
DO - https://doi.org/10.1007/978-3-030-57231-0_26
M3 - Chapter
C2 - 36876289
SN - 9783030572303
T3 - PET and SPECT in Psychiatry: Second Edition
SP - 841
EP - 860
BT - PET and SPECT in Psychiatry: Second Edition
PB - Springer International Publishing
ER -