TY - JOUR
T1 - Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer's disease
AU - Bilderbeck, Amy C.
AU - Penninx, Brenda W. J. H.
AU - Arango, Celso
AU - van der Wee, Nic
AU - Kahn, René
AU - Winter-van Rossum, Inge
AU - Hayen, Anja
AU - Kas, Martien J.
AU - Post, Anke
AU - Dawson, Gerard R.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Trans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential. In this manuscript we describe the approach and protocol for an exploratory study, PRISM (Psychiatric Ratings using Intermediate Stratified Markers), that will be conducted to explore the biomarkers in schizophrenia (SZ) and Alzheimer's Disease (AD) that may be related to a common symptom, social withdrawal. Patient participants (N = 72 SZ and N = 72 AD study completers), will complete a series of fMRI, EEG, and behavioural paradigms, as well as contributing blood-derived (e.g. epigenetic) and smartphone data related to social behaviour. Self- as well as caregiver- and researcher-reported assessments will be provided to characterise social withdrawal. Normative data will also be collected from a group of healthy controls (N = 48 study completers), half of whom will be matched in terms of age and gender distribution to the SZ and AD group, respectively. Thus we will explore both differentiation and cross-diagnostic overlap in the biomarkers associated with different levels of social withdrawal in SZ and AD. In this way we aim to provide a deeper understanding of the biological underpinnings of symptomatology common to both disorders, and provide insights into novel treatment targets and future drug development approaches.
AB - Trans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential. In this manuscript we describe the approach and protocol for an exploratory study, PRISM (Psychiatric Ratings using Intermediate Stratified Markers), that will be conducted to explore the biomarkers in schizophrenia (SZ) and Alzheimer's Disease (AD) that may be related to a common symptom, social withdrawal. Patient participants (N = 72 SZ and N = 72 AD study completers), will complete a series of fMRI, EEG, and behavioural paradigms, as well as contributing blood-derived (e.g. epigenetic) and smartphone data related to social behaviour. Self- as well as caregiver- and researcher-reported assessments will be provided to characterise social withdrawal. Normative data will also be collected from a group of healthy controls (N = 48 study completers), half of whom will be matched in terms of age and gender distribution to the SZ and AD group, respectively. Thus we will explore both differentiation and cross-diagnostic overlap in the biomarkers associated with different levels of social withdrawal in SZ and AD. In this way we aim to provide a deeper understanding of the biological underpinnings of symptomatology common to both disorders, and provide insights into novel treatment targets and future drug development approaches.
KW - Alzheimer's disease
KW - Cognition
KW - EEG
KW - MRI
KW - RDOC
KW - Schizophrenia
KW - Social withdrawal
UR - http://www.scopus.com/inward/record.url?scp=85053708409&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2018.06.019
DO - https://doi.org/10.1016/j.neubiorev.2018.06.019
M3 - Comment/Letter to the editor
C2 - 29940238
SN - 0149-7634
VL - 97
SP - 87
EP - 93
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 2
ER -