Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

Erfan Nur; Bart J. Biemond; Hans-Martin Otten; Dees P. Brandjes; John-John B. Schnog

doi:https://doi.org/10.1002/ajh.22012

Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

Erfan Nur, Bart J. Biemond, Hans-Martin Otten, Dees P. Brandjes, John-John B. Schnog

Research output: Contribution to journal › Review article › Academic › peer-review

157 Citations (Scopus)

Abstract

Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-) products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Am. J. Hematol. 86:484-489, 2011. (C) 2011 Wiley-Liss, Inc

Original language	English
Pages (from-to)	484-489
Journal	American journal of hematology
Volume	86
Issue number	6
DOIs	https://doi.org/10.1002/ajh.22012
Publication status	Published - 2011

Access to Document

https://doi.org/10.1002/ajh.22012

Cite this

@article{07bcd4b3546d43d3b4a7c00c4fa0095a,

title = "Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management",

abstract = "Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-) products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Am. J. Hematol. 86:484-489, 2011. (C) 2011 Wiley-Liss, Inc",

author = "Erfan Nur and Biemond, {Bart J.} and Hans-Martin Otten and Brandjes, {Dees P.} and Schnog, {John-John B.}",

year = "2011",

doi = "https://doi.org/10.1002/ajh.22012",

language = "English",

volume = "86",

pages = "484--489",

journal = "American journal of hematology",

issn = "0361-8609",

publisher = "Wiley-Liss Inc.",

number = "6",

}

TY - JOUR

T1 - Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

AU - Nur, Erfan

AU - Biemond, Bart J.

AU - Otten, Hans-Martin

AU - Brandjes, Dees P.

AU - Schnog, John-John B.

PY - 2011

Y1 - 2011

N2 - Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-) products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Am. J. Hematol. 86:484-489, 2011. (C) 2011 Wiley-Liss, Inc

AB - Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-) products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Am. J. Hematol. 86:484-489, 2011. (C) 2011 Wiley-Liss, Inc

U2 - https://doi.org/10.1002/ajh.22012

DO - https://doi.org/10.1002/ajh.22012

M3 - Review article

C2 - 21544855

SN - 0361-8609

VL - 86

SP - 484

EP - 489

JO - American journal of hematology

JF - American journal of hematology

IS - 6

ER -