P4 ATPases - The physiological relevance of lipid flipping transporters

Coen C. Paulusma; Ronald P. J. Oude Elferink

doi:https://doi.org/10.1016/j.febslet.2010.04.071

P4 ATPases - The physiological relevance of lipid flipping transporters

Coen C. Paulusma, Ronald P. J. Oude Elferink

Research output: Contribution to journal › Review article › Academic › peer-review

40 Citations (Scopus)

Abstract

P4 ATPases are integral transmembrane proteins implicated in phospholipid translocation from the exoplasmic to the cytosolic leaflet of biological membranes. Our present knowledge on the cellular physiology of P4 ATPases is mostly derived from studies in the yeast Saccharomyces cerevisiae, where P4 ATPases play a pivotal role in the biogenesis of intracellular transport vesicles, polarized protein transport and protein maturation. In contrast, the physiological and cellular functions of mammalian P4 ATPases are largely unexplored. P4 ATPases act in concert with members of the CDC50 protein family, which are putative beta-subunits for P4 ATPases. This review highlights the current status of a slowly emerging research field and emphasizes the contribution of P4 ATPases to the vesicle-generating machinery. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

Original language	English
Pages (from-to)	2708-2716
Journal	FEBS letters
Volume	584
Issue number	13
DOIs	https://doi.org/10.1016/j.febslet.2010.04.071
Publication status	Published - 2010

Access to Document

https://doi.org/10.1016/j.febslet.2010.04.071

Cite this

@article{bbd33bbd98fc49c1a5b22eec52b50e6a,

title = "P4 ATPases - The physiological relevance of lipid flipping transporters",

abstract = "P4 ATPases are integral transmembrane proteins implicated in phospholipid translocation from the exoplasmic to the cytosolic leaflet of biological membranes. Our present knowledge on the cellular physiology of P4 ATPases is mostly derived from studies in the yeast Saccharomyces cerevisiae, where P4 ATPases play a pivotal role in the biogenesis of intracellular transport vesicles, polarized protein transport and protein maturation. In contrast, the physiological and cellular functions of mammalian P4 ATPases are largely unexplored. P4 ATPases act in concert with members of the CDC50 protein family, which are putative beta-subunits for P4 ATPases. This review highlights the current status of a slowly emerging research field and emphasizes the contribution of P4 ATPases to the vesicle-generating machinery. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved",

author = "Paulusma, {Coen C.} and {Oude Elferink}, {Ronald P. J.}",

year = "2010",

doi = "https://doi.org/10.1016/j.febslet.2010.04.071",

language = "English",

volume = "584",

pages = "2708--2716",

journal = "FEBS letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "13",

}

TY - JOUR

T1 - P4 ATPases - The physiological relevance of lipid flipping transporters

AU - Paulusma, Coen C.

AU - Oude Elferink, Ronald P. J.

PY - 2010

Y1 - 2010

N2 - P4 ATPases are integral transmembrane proteins implicated in phospholipid translocation from the exoplasmic to the cytosolic leaflet of biological membranes. Our present knowledge on the cellular physiology of P4 ATPases is mostly derived from studies in the yeast Saccharomyces cerevisiae, where P4 ATPases play a pivotal role in the biogenesis of intracellular transport vesicles, polarized protein transport and protein maturation. In contrast, the physiological and cellular functions of mammalian P4 ATPases are largely unexplored. P4 ATPases act in concert with members of the CDC50 protein family, which are putative beta-subunits for P4 ATPases. This review highlights the current status of a slowly emerging research field and emphasizes the contribution of P4 ATPases to the vesicle-generating machinery. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

AB - P4 ATPases are integral transmembrane proteins implicated in phospholipid translocation from the exoplasmic to the cytosolic leaflet of biological membranes. Our present knowledge on the cellular physiology of P4 ATPases is mostly derived from studies in the yeast Saccharomyces cerevisiae, where P4 ATPases play a pivotal role in the biogenesis of intracellular transport vesicles, polarized protein transport and protein maturation. In contrast, the physiological and cellular functions of mammalian P4 ATPases are largely unexplored. P4 ATPases act in concert with members of the CDC50 protein family, which are putative beta-subunits for P4 ATPases. This review highlights the current status of a slowly emerging research field and emphasizes the contribution of P4 ATPases to the vesicle-generating machinery. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

U2 - https://doi.org/10.1016/j.febslet.2010.04.071

DO - https://doi.org/10.1016/j.febslet.2010.04.071

M3 - Review article

C2 - 20450914

SN - 0014-5793

VL - 584

SP - 2708

EP - 2716

JO - FEBS letters

JF - FEBS letters

IS - 13

ER -