Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report

Jean Bousquet; Mohamed H. Shamji; Josep M. Anto; Holger J. Schünemann; G. Walter Canonica; Marek Jutel; Stefano del Giacco; Torsten Zuberbier; Oliver Pfaar; Joao A. Fonseca; Bernardo Sousa-Pinto; Ludger Klimek; Wienczyslawa Czarlewski; Anna Bedbrook; Rita Amaral; Ignacio J. Ansotegui; Sinthia Bosnic-Anticevich; Fulvio Braido; Claudia Chaves Loureiro; Bilun Gemicioglu; Tari Haahtela; Marek Kulus; Piotr Kuna; Maciej Kupczyk; Paolo M. Matricardi; Frederico S. Regateiro; Boleslaw Samolinski; Mikhail Sofiev; Sanna Toppila-Salmi; Arunas Valiulis; Maria Teresa Ventura; Cristina Barbara; Karl C. Bergmann; Michael Bewick; Hubert Blain; Matteo Bonini; Louis-Philippe Boulet; Rodolphe Bourret; Guy Brusselle; Luisa Brussino; Roland Buhl; Victoria Cardona; Thomas Casale; Lorenzo Cecchi; Denis Charpin; Ivan Cherrez-Ojeda; Derek K. Chu; Cemal Cingi; Elisio M. Costa; Alvaro A. Cruz; Philippe Devillier; Stephanie Dramburg; Wytske J. Fokkens; Maia Gotua; Enrico Heffler; Zhanat Ispayeva; Juan Carlos Ivancevich; Guy Joos; Igor Kaidashev; Helga Kraxner; Violeta Kvedariene; D. sirée E. Larenas-Linnemann; Daniel Laune; Olga Lourenço; Renaud Louis; Mika Makela; Michael Makris; Marcus Maurer; Erik Melén; Yann Micheli; Mario Morais-Almeida; Joaquim Mullol; Marek Niedoszytko; Robyn O'Hehir; Yoshitaka Okamoto; Heidi Olze; Nikolaos G. Papadopoulos; Alberto Papi; Vincenzo Patella; Benoit Pétré; Nhân Pham-Thi; Francesca Puggioni; Santiago Quirce; Nicolas Roche; Philip W. Rouadi; Ana Sá-Sousa; Hironori Sagara; Joaquin Sastre; Nicola Scichilone; Aziz Sheikh; Milan Sova; Charlotte Suppli Ulrik; Luis Taborda-Barata; Ana Todo-Bom; Maria J. Torres; Ioanna Tsiligianni; Omar S. Usmani; Erkka Valovirta; Tuula Vasankari; Rafael José Vieira; Dana Wallace; Susan Waserman; Mihaela Zidarn; Arzu Yorgancioglu; Luo Zhang; Tomas Chivato; Markus Ollert

doi:https://doi.org/10.1111/all.15740

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report

Jean Bousquet, Mohamed H. Shamji, Josep M. Anto, Holger J. Schünemann, G. Walter Canonica, Marek Jutel, Stefano del Giacco, Torsten Zuberbier, Oliver Pfaar, Joao A. Fonseca, Bernardo Sousa-Pinto, Ludger Klimek, Wienczyslawa Czarlewski, Anna Bedbrook, Rita Amaral, Ignacio J. Ansotegui, Sinthia Bosnic-Anticevich, Fulvio Braido, Claudia Chaves Loureiro, Bilun GemiciogluTari Haahtela, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Paolo M. Matricardi, Frederico S. Regateiro, Boleslaw Samolinski, Mikhail Sofiev, Sanna Toppila-Salmi, Arunas Valiulis, Maria Teresa Ventura, Cristina Barbara, Karl C. Bergmann, Michael Bewick, Hubert Blain, Matteo Bonini, Louis-Philippe Boulet, Rodolphe Bourret, Guy Brusselle, Luisa Brussino, Roland Buhl, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Ivan Cherrez-Ojeda, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephanie Dramburg, Wytske J. Fokkens, Maia Gotua, Enrico Heffler, Zhanat Ispayeva, Juan Carlos Ivancevich, Guy Joos, Igor Kaidashev, Helga Kraxner, Violeta Kvedariene, D. sirée E. Larenas-Linnemann, Daniel Laune, Olga Lourenço, Renaud Louis, Mika Makela, Michael Makris, Marcus Maurer, Erik Melén, Yann Micheli, Mario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Robyn O'Hehir, Yoshitaka Okamoto, Heidi Olze, Nikolaos G. Papadopoulos, Alberto Papi, Vincenzo Patella, Benoit Pétré, Nhân Pham-Thi, Francesca Puggioni, Santiago Quirce, Nicolas Roche, Philip W. Rouadi, Ana Sá-Sousa, Hironori Sagara, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Milan Sova, Charlotte Suppli Ulrik, Luis Taborda-Barata, Ana Todo-Bom, Maria J. Torres, Ioanna Tsiligianni, Omar S. Usmani, Erkka Valovirta, Tuula Vasankari, Rafael José Vieira, Dana Wallace, Susan Waserman, Mihaela Zidarn, Arzu Yorgancioglu, Luo Zhang, Tomas Chivato, Markus Ollert

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

Original language	English
Pages (from-to)	1758-1776
Number of pages	19
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	78
Issue number	7
DOIs	https://doi.org/10.1111/all.15740
Publication status	Published - 1 Jul 2023

Keywords

ARIA
EAACI
apps
digital health
rhinitis

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https://doi.org/10.1111/all.15740

Cite this

Bousquet, J., Shamji, M. H., Anto, J. M., Schünemann, H. J., Canonica, G. W., Jutel, M., del Giacco, S., Zuberbier, T., Pfaar, O., Fonseca, J. A., Sousa-Pinto, B., Klimek, L., Czarlewski, W., Bedbrook, A., Amaral, R., Ansotegui, I. J., Bosnic-Anticevich, S., Braido, F., Chaves Loureiro, C., ... Ollert, M. (2023). Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report. Allergy: European Journal of Allergy and Clinical Immunology, 78(7), 1758-1776. https://doi.org/10.1111/all.15740

@article{9191a0d81ac146d48c916d37131acadd,

title = "Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report",

abstract = "Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.",

keywords = "ARIA, EAACI, apps, digital health, rhinitis",

author = "Jean Bousquet and Shamji, {Mohamed H.} and Anto, {Josep M.} and Sch{\"u}nemann, {Holger J.} and Canonica, {G. Walter} and Marek Jutel and Stefano del Giacco and Torsten Zuberbier and Oliver Pfaar and Fonseca, {Joao A.} and Bernardo Sousa-Pinto and Ludger Klimek and Wienczyslawa Czarlewski and Anna Bedbrook and Rita Amaral and Ansotegui, {Ignacio J.} and Sinthia Bosnic-Anticevich and Fulvio Braido and Claudia Chaves Loureiro and Bilun Gemicioglu and Tari Haahtela and Marek Kulus and Piotr Kuna and Maciej Kupczyk and Paolo M. Matricardi and Regateiro, {Frederico S.} and Boleslaw Samolinski and Mikhail Sofiev and Sanna Toppila-Salmi and Arunas Valiulis and Ventura, {Maria Teresa} and Cristina Barbara and Bergmann, {Karl C.} and Michael Bewick and Hubert Blain and Matteo Bonini and Louis-Philippe Boulet and Rodolphe Bourret and Guy Brusselle and Luisa Brussino and Roland Buhl and Victoria Cardona and Thomas Casale and Lorenzo Cecchi and Denis Charpin and Ivan Cherrez-Ojeda and Chu, {Derek K.} and Cemal Cingi and Costa, {Elisio M.} and Alvaro A. Cruz and Philippe Devillier and Stephanie Dramburg and Wytske J. Fokkens and Maia Gotua and Enrico Heffler and Zhanat Ispayeva and Ivancevich, {Juan Carlos} and Guy Joos and Igor Kaidashev and Helga Kraxner and Violeta Kvedariene and Larenas-Linnemann, {D. sir{\'e}e E.} and Daniel Laune and Olga Louren{\c c}o and Renaud Louis and Mika Makela and Michael Makris and Marcus Maurer and Erik Mel{\'e}n and Yann Micheli and Mario Morais-Almeida and Joaquim Mullol and Marek Niedoszytko and Robyn O'Hehir and Yoshitaka Okamoto and Heidi Olze and Papadopoulos, {Nikolaos G.} and Alberto Papi and Vincenzo Patella and Benoit P{\'e}tr{\'e} and Nh{\^a}n Pham-Thi and Francesca Puggioni and Santiago Quirce and Nicolas Roche and Philip W. Rouadi and Ana S{\'a}-Sousa and Hironori Sagara and Joaquin Sastre and Nicola Scichilone and Aziz Sheikh and Milan Sova and Charlotte Suppli Ulrik and Luis Taborda-Barata and Ana Todo-Bom and Maria J. Torres and Ioanna Tsiligianni and Usmani, {Omar S.} and Erkka Valovirta and Tuula Vasankari and Vieira, {Rafael Jos{\'e}} and Dana Wallace and Susan Waserman and Mihaela Zidarn and Arzu Yorgancioglu and Luo Zhang and Tomas Chivato and Markus Ollert",

note = "Funding Information: MASK‐air{\textregistered} has been supported by Charit{\'e} Universit{\"a}tsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallerg{\`e}nes‐Greer and Uriach. Publisher Copyright: {\textcopyright} 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.",

year = "2023",

month = jul,

day = "1",

doi = "https://doi.org/10.1111/all.15740",

language = "English",

volume = "78",

pages = "1758--1776",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell",

number = "7",

}

Bousquet, J, Shamji, MH, Anto, JM, Schünemann, HJ, Canonica, GW, Jutel, M, del Giacco, S, Zuberbier, T, Pfaar, O, Fonseca, JA, Sousa-Pinto, B, Klimek, L, Czarlewski, W, Bedbrook, A, Amaral, R, Ansotegui, IJ, Bosnic-Anticevich, S, Braido, F, Chaves Loureiro, C, Gemicioglu, B, Haahtela, T, Kulus, M, Kuna, P, Kupczyk, M, Matricardi, PM, Regateiro, FS, Samolinski, B, Sofiev, M, Toppila-Salmi, S, Valiulis, A, Ventura, MT, Barbara, C, Bergmann, KC, Bewick, M, Blain, H, Bonini, M, Boulet, L-P, Bourret, R, Brusselle, G, Brussino, L, Buhl, R, Cardona, V, Casale, T, Cecchi, L, Charpin, D, Cherrez-Ojeda, I, Chu, DK, Cingi, C, Costa, EM, Cruz, AA, Devillier, P, Dramburg, S, Fokkens, WJ, Gotua, M, Heffler, E, Ispayeva, Z, Ivancevich, JC, Joos, G, Kaidashev, I, Kraxner, H, Kvedariene, V, Larenas-Linnemann, DSE, Laune, D, Lourenço, O, Louis, R, Makela, M, Makris, M, Maurer, M, Melén, E, Micheli, Y, Morais-Almeida, M, Mullol, J, Niedoszytko, M, O'Hehir, R, Okamoto, Y, Olze, H, Papadopoulos, NG, Papi, A, Patella, V, Pétré, B, Pham-Thi, N, Puggioni, F, Quirce, S, Roche, N, Rouadi, PW, Sá-Sousa, A, Sagara, H, Sastre, J, Scichilone, N, Sheikh, A, Sova, M, Suppli Ulrik, C, Taborda-Barata, L, Todo-Bom, A, Torres, MJ, Tsiligianni, I, Usmani, OS, Valovirta, E, Vasankari, T, Vieira, RJ, Wallace, D, Waserman, S, Zidarn, M, Yorgancioglu, A, Zhang, L, Chivato, T & Ollert, M 2023, 'Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report', Allergy: European Journal of Allergy and Clinical Immunology, vol. 78, no. 7, pp. 1758-1776. https://doi.org/10.1111/all.15740

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report. / Bousquet, Jean; Shamji, Mohamed H.; Anto, Josep M. et al.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 78, No. 7, 01.07.2023, p. 1758-1776.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Patient-centered digital biomarkers for allergic respiratory diseases and asthma

T2 - The ARIA-EAACI approach – ARIA-EAACI Task Force Report

AU - Bousquet, Jean

AU - Shamji, Mohamed H.

AU - Anto, Josep M.

AU - Schünemann, Holger J.

AU - Canonica, G. Walter

AU - Jutel, Marek

AU - del Giacco, Stefano

AU - Zuberbier, Torsten

AU - Pfaar, Oliver

AU - Fonseca, Joao A.

AU - Sousa-Pinto, Bernardo

AU - Klimek, Ludger

AU - Czarlewski, Wienczyslawa

AU - Bedbrook, Anna

AU - Amaral, Rita

AU - Ansotegui, Ignacio J.

AU - Bosnic-Anticevich, Sinthia

AU - Braido, Fulvio

AU - Chaves Loureiro, Claudia

AU - Gemicioglu, Bilun

AU - Haahtela, Tari

AU - Kulus, Marek

AU - Kuna, Piotr

AU - Kupczyk, Maciej

AU - Matricardi, Paolo M.

AU - Regateiro, Frederico S.

AU - Samolinski, Boleslaw

AU - Sofiev, Mikhail

AU - Toppila-Salmi, Sanna

AU - Valiulis, Arunas

AU - Ventura, Maria Teresa

AU - Barbara, Cristina

AU - Bergmann, Karl C.

AU - Bewick, Michael

AU - Blain, Hubert

AU - Bonini, Matteo

AU - Boulet, Louis-Philippe

AU - Bourret, Rodolphe

AU - Brusselle, Guy

AU - Brussino, Luisa

AU - Buhl, Roland

AU - Cardona, Victoria

AU - Casale, Thomas

AU - Cecchi, Lorenzo

AU - Charpin, Denis

AU - Cherrez-Ojeda, Ivan

AU - Chu, Derek K.

AU - Cingi, Cemal

AU - Costa, Elisio M.

AU - Cruz, Alvaro A.

AU - Devillier, Philippe

AU - Dramburg, Stephanie

AU - Fokkens, Wytske J.

AU - Gotua, Maia

AU - Heffler, Enrico

AU - Ispayeva, Zhanat

AU - Ivancevich, Juan Carlos

AU - Joos, Guy

AU - Kaidashev, Igor

AU - Kraxner, Helga

AU - Kvedariene, Violeta

AU - Larenas-Linnemann, D. sirée E.

AU - Laune, Daniel

AU - Lourenço, Olga

AU - Louis, Renaud

AU - Makela, Mika

AU - Makris, Michael

AU - Maurer, Marcus

AU - Melén, Erik

AU - Micheli, Yann

AU - Morais-Almeida, Mario

AU - Mullol, Joaquim

AU - Niedoszytko, Marek

AU - O'Hehir, Robyn

AU - Okamoto, Yoshitaka

AU - Olze, Heidi

AU - Papadopoulos, Nikolaos G.

AU - Papi, Alberto

AU - Patella, Vincenzo

AU - Pétré, Benoit

AU - Pham-Thi, Nhân

AU - Puggioni, Francesca

AU - Quirce, Santiago

AU - Roche, Nicolas

AU - Rouadi, Philip W.

AU - Sá-Sousa, Ana

AU - Sagara, Hironori

AU - Sastre, Joaquin

AU - Scichilone, Nicola

AU - Sheikh, Aziz

AU - Sova, Milan

AU - Suppli Ulrik, Charlotte

AU - Taborda-Barata, Luis

AU - Todo-Bom, Ana

AU - Torres, Maria J.

AU - Tsiligianni, Ioanna

AU - Usmani, Omar S.

AU - Valovirta, Erkka

AU - Vasankari, Tuula

AU - Vieira, Rafael José

AU - Wallace, Dana

AU - Waserman, Susan

AU - Zidarn, Mihaela

AU - Yorgancioglu, Arzu

AU - Zhang, Luo

AU - Chivato, Tomas

AU - Ollert, Markus

N1 - Funding Information: MASK‐air® has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. Publisher Copyright: © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

AB - Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

KW - ARIA

KW - EAACI

KW - apps

KW - digital health

KW - rhinitis

UR - http://www.scopus.com/inward/record.url?scp=85164233199&partnerID=8YFLogxK

U2 - https://doi.org/10.1111/all.15740

DO - https://doi.org/10.1111/all.15740

M3 - Article

C2 - 37042071

SN - 0105-4538

VL - 78

SP - 1758

EP - 1776

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 7

ER -

Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach – ARIA-EAACI Task Force Report

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