TY - JOUR
T1 - Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
AU - Duits, Flora H.
AU - Martinez-Lage, Pablo
AU - Paquet, Claire
AU - Engelborghs, Sebastiaan
AU - Lleo, Alberto
AU - Hausner, Lucrezia
AU - Molinuevo, Jose L.
AU - Stomrud, Erik
AU - Farotti, Lucia
AU - Ramakers, Inez H. G. B.
AU - Tsolaki, Magda
AU - Skarsgard, Constance
AU - Astrand, Ragnar
AU - Wallin, Anders
AU - Vyhnalek, Martin
AU - Holmber-Clausen, Marie
AU - Forlenza, Orestes V.
AU - Ghezzi, Laura
AU - Ingelsson, Martin
AU - Hoff, Erik I.
AU - Roks, Gerwin
AU - de Mendonca, Alexandre
AU - Papma, Janne M.
AU - Izagirre, Andrea
AU - Taga, Mariko
AU - Struyfs, Hanne
AU - Alcolea, Daniel A.
AU - Froelich, Lutz
AU - Balasa, Mircea
AU - Minthon, Lennart
AU - Twisk, Jos W. R.
AU - Persson, Staffan
AU - Zetterberg, Henrik
AU - van der Flier, Wiesje M.
AU - Teunissen, Charlotte E.
AU - Scheltens, Philip
AU - Blennow, Kaj
PY - 2016/2
Y1 - 2016/2
N2 - Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient‐acceptance of LP, incidence of and risk factors for post‐LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post‐LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post‐LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
AB - Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient‐acceptance of LP, incidence of and risk factors for post‐LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post‐LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post‐LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
KW - Alzheimer's disease
KW - Cognitive disorders
KW - Lumbar puncture
KW - Memory clinic
KW - Multicenter study on LP feasibility
KW - Post-LP complications
KW - Post-LP headache
U2 - https://doi.org/10.1016/j.jalz.2015.08.003
DO - https://doi.org/10.1016/j.jalz.2015.08.003
M3 - Article
C2 - 26368321
SN - 1552-5260
VL - 12
SP - 154
EP - 163
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
IS - 2
ER -