Abstract
Prescriptions and use of glucagon-like peptide-1 (GLP-1) receptor agonists are increasing dramatically, as indications are expanding from the treatment of diabetes mellitus to weight loss for people with obesity. As GLP-1 receptor agonists delay gastric emptying, perioperative healthcare practitioners could be concerned about an increased risk for pulmonary aspiration during general anaesthesia. We summarise relevant medical literature and provide evidence-based recommendations for perioperative care for people taking GLP-1 receptor agonists. GLP-1 receptor agonists delay gastric emptying; however, ongoing treatment attenuates this effect. The risk of aspiration during general anaesthesia is unknown. However, we advise caution in patients who recently commenced on GLP-1 receptor agonists. After over 12 weeks of treatment, standard fasting times likely suffice to manage the risk of pulmonary aspiration for most otherwise low-risk patients.
Original language | English |
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Pages (from-to) | 644-648 |
Number of pages | 5 |
Journal | British Journal of Anaesthesia |
Volume | 132 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2024 |
Keywords
- diabetes mellitus
- gastric emptying
- glucagon-like peptide-1 receptor agonists
- obesity
- pulmonary aspiration