Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype

P. P. Landburg; T. Teerlink; B. J. Biemond; D. P. M. Brandjes; F. A. J. Muskiet; A. J. Duits; J. B. Schnog

doi:https://doi.org/10.1016/j.bcmd.2010.02.005

Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype

P. P. Landburg, T. Teerlink, B. J. Biemond, D. P. M. Brandjes, F. A. J. Muskiet, A. J. Duits, J. B. Schnog

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Abstract

Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD

Original language	English
Pages (from-to)	229-232
Journal	Blood cells, molecules & diseases
Volume	44
Issue number	4
DOIs	https://doi.org/10.1016/j.bcmd.2010.02.005
Publication status	Published - 2010

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https://doi.org/10.1016/j.bcmd.2010.02.005

Cite this

@article{3ba8469fc29e46b69fb88c0530751170,

title = "Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype",

abstract = "Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD",

author = "Landburg, {P. P.} and T. Teerlink and Biemond, {B. J.} and Brandjes, {D. P. M.} and Muskiet, {F. A. J.} and Duits, {A. J.} and Schnog, {J. B.}",

year = "2010",

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language = "English",

volume = "44",

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journal = "Blood cells, molecules & diseases",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype

AU - Landburg, P. P.

AU - Teerlink, T.

AU - Biemond, B. J.

AU - Brandjes, D. P. M.

AU - Muskiet, F. A. J.

AU - Duits, A. J.

AU - Schnog, J. B.

PY - 2010

Y1 - 2010

N2 - Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD

AB - Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD

U2 - https://doi.org/10.1016/j.bcmd.2010.02.005

DO - https://doi.org/10.1016/j.bcmd.2010.02.005

M3 - Article

C2 - 20185345

SN - 1079-9796

VL - 44

SP - 229

EP - 232

JO - Blood cells, molecules & diseases

JF - Blood cells, molecules & diseases

IS - 4

ER -