TY - JOUR
T1 - Practice variation and outcomes of minimally invasive minor liver resections in patients with colorectal liver metastases
T2 - a population-based study
AU - de Graaff, Michelle R.
AU - Klaase, Joost M.
AU - de Kleine, Ruben
AU - Elfrink, Arthur K. E.
AU - Swijnenburg, Rutger-Jan
AU - M. Zonderhuis, Babs
AU - D. Mieog, J. Sven
AU - Derksen, Wouter J. M.
AU - Hagendoorn, Jeroen
AU - van den Boezem, Peter B.
AU - Rijken, Arjen M.
AU - Gobardhan, Paul D.
AU - Marsman, Hendrik A.
AU - Liem, Mike S. L.
AU - Leclercq, Wouter K. G.
AU - van Heek, Tjarda N. T.
AU - Pantijn, Gijs A.
AU - Bosscha, Koop
AU - Belt, Eric J. T.
AU - Vermaas, Maarten
AU - Torrenga, Hans
AU - Manusama, Eric R.
AU - van den Tol, Petrousjka
AU - Oosterling, Steven J.
AU - den Dulk, Marcel
AU - Grünhagen, Dirk J.
AU - for Dutch Hepato Biliary Audit Group, Collaborators
AU - Kok, Niels F. M.
N1 - Funding Information: The authors would like to thank all surgeons, interventional radiologists and administrative nurses for data registration in the DHBA database, as well as the Dutch Hepato Biliary Audit Group for scientific input. For Dutch Hepato Biliary Audit Group, Collaborators: Members of the Dutch Hepato Biliary Audit Group and collaborators should be listed as authors and should be Pubmed citable. Collaborators: Cornelis Verhoef, Carlijn I. Buis, Marieke T. de Boer, Marc G.H. Besselink, Andries E. Braat, Frederik J.H. Hoogwater, Esther C.J. Consten, Christiaan van der Leij, Mark C. Burgmans. Publisher Copyright: © 2023, The Author(s).
PY - 2023/8
Y1 - 2023/8
N2 - Introduction: In 2017, the Southampton guideline stated that minimally invasive liver resections (MILR) should considered standard practice for minor liver resections. This study aimed to assess recent implementation rates of minor MILR, factors associated with performing MILR, hospital variation, and outcomes in patients with colorectal liver metastases (CRLM). Methods: This population-based study included all patients who underwent minor liver resection for CRLM in the Netherlands between 2014 and 2021. Factors associated with MILR and nationwide hospital variation were assessed using multilevel multivariable logistic regression. Propensity-score matching (PSM) was applied to compare outcomes between minor MILR and minor open liver resections. Overall survival (OS) was assessed with Kaplan–Meier analysis on patients operated until 2018. Results: Of 4,488 patients included, 1,695 (37.8%) underwent MILR. PSM resulted in 1,338 patients in each group. Implementation of MILR increased to 51.2% in 2021. Factors associated with not performing MILR included treatment with preoperative chemotherapy (aOR 0.61 CI:0.50–0.75, p < 0.001), treatment in a tertiary referral hospital (aOR 0.57 CI:0.50–0.67, p < 0.001), and larger diameter and number of CRLM. Significant hospital variation was observed in use of MILR (7.5% to 93.0%). After case-mix correction, six hospitals performed fewer, and six hospitals performed more MILRs than expected. In the PSM cohort, MILR was associated with a decrease in blood loss (aOR 0.99 CI:0.99–0.99, p < 0.01), cardiac complications (aOR 0.29, CI:0.10–0.70, p = 0.009), IC admissions (aOR 0.66, CI:0.50–0.89, p = 0.005), and shorter hospital stay (aOR CI:0.94–0.99, p < 0.01). Five-year OS rates for MILR and OLR were 53.7% versus 48.6%, p = 0.21. Conclusion: Although uptake of MILR is increasing in the Netherlands, significant hospital variation remains. MILR benefits short-term outcomes, while overall survival is comparable to open liver surgery. Graphical abstract: [Figure not available: see fulltext.].
AB - Introduction: In 2017, the Southampton guideline stated that minimally invasive liver resections (MILR) should considered standard practice for minor liver resections. This study aimed to assess recent implementation rates of minor MILR, factors associated with performing MILR, hospital variation, and outcomes in patients with colorectal liver metastases (CRLM). Methods: This population-based study included all patients who underwent minor liver resection for CRLM in the Netherlands between 2014 and 2021. Factors associated with MILR and nationwide hospital variation were assessed using multilevel multivariable logistic regression. Propensity-score matching (PSM) was applied to compare outcomes between minor MILR and minor open liver resections. Overall survival (OS) was assessed with Kaplan–Meier analysis on patients operated until 2018. Results: Of 4,488 patients included, 1,695 (37.8%) underwent MILR. PSM resulted in 1,338 patients in each group. Implementation of MILR increased to 51.2% in 2021. Factors associated with not performing MILR included treatment with preoperative chemotherapy (aOR 0.61 CI:0.50–0.75, p < 0.001), treatment in a tertiary referral hospital (aOR 0.57 CI:0.50–0.67, p < 0.001), and larger diameter and number of CRLM. Significant hospital variation was observed in use of MILR (7.5% to 93.0%). After case-mix correction, six hospitals performed fewer, and six hospitals performed more MILRs than expected. In the PSM cohort, MILR was associated with a decrease in blood loss (aOR 0.99 CI:0.99–0.99, p < 0.01), cardiac complications (aOR 0.29, CI:0.10–0.70, p = 0.009), IC admissions (aOR 0.66, CI:0.50–0.89, p = 0.005), and shorter hospital stay (aOR CI:0.94–0.99, p < 0.01). Five-year OS rates for MILR and OLR were 53.7% versus 48.6%, p = 0.21. Conclusion: Although uptake of MILR is increasing in the Netherlands, significant hospital variation remains. MILR benefits short-term outcomes, while overall survival is comparable to open liver surgery. Graphical abstract: [Figure not available: see fulltext.].
KW - Colorectal liver metastases
KW - Hospital variation
KW - Minimally invasive liver surgery
KW - Minor liver resection
KW - Overall survival
KW - Short-term outcomes
UR - http://www.scopus.com/inward/record.url?scp=85153277620&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00464-023-10010-3
DO - https://doi.org/10.1007/s00464-023-10010-3
M3 - Article
C2 - 37072639
SN - 0930-2794
VL - 37
SP - 5916
EP - 5930
JO - Surgical endoscopy
JF - Surgical endoscopy
IS - 8
ER -