TY - JOUR
T1 - Predicting sojourn times across dementia disease stages, institutionalization, and mortality
AU - Tate, Ashley E.
AU - Bouteloup, Vincent
AU - van Maurik, Ingrid S.
AU - Jean, Delphine
AU - Mank, Arenda
AU - Speh, Andreja
AU - Boilet, Valerie
AU - van Harten, Argonde
AU - Eriksdotter, Maria
AU - Wimo, Anders
AU - Dufouil, Carole
AU - van der Flier, Wiesje M.
AU - Jönsson, Linus
N1 - Funding Information: The project is supported through EU Joint Programme‐ Neurodegenerative Disease Research (JPND) ADDITION project. The project is supported through the following funding organization under the aegis of JPND, www.jpnd.edu and a research grant from the Swedish Research Council for Health, Working Life and Welfare (FORTE), 2018‐01887. Funding Information: Research of Alzheimer center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting Steun Alzheimercentrum Amsterdam. The chair of Wiesje van der Flier is supported by the Pasman stichting. The clinical database structure was developed with funding from Stichting Dioraphte. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: Inferring the timeline from mild cognitive impairment (MCI) to severe dementia is pivotal for patients, clinicians, and researchers. Literature is sparse and often contains few patients. We aim to determine the time spent in MCI, mild-, moderate-, severe dementia, and institutionalization until death. METHODS: Multistate modeling with Cox regression was used to obtain the sojourn time. Covariates were age at baseline, sex, amyloid status, and Alzheimer's disease (AD) or other dementia diagnosis. The sample included a register (SveDem) and memory clinics (Amsterdam Dementia Cohort and Memento). RESULTS: Using 80,543 patients, the sojourn time from clinically identified MCI to death across all patient groups ranged from 6.20 (95% confidence interval [CI]: 5.57–6.98) to 10.08 (8.94–12.18) years. DISCUSSION: Generally, sojourn time was inversely associated with older age at baseline, males, and AD diagnosis. The results provide key estimates for researchers and clinicians to estimate prognosis.
AB - INTRODUCTION: Inferring the timeline from mild cognitive impairment (MCI) to severe dementia is pivotal for patients, clinicians, and researchers. Literature is sparse and often contains few patients. We aim to determine the time spent in MCI, mild-, moderate-, severe dementia, and institutionalization until death. METHODS: Multistate modeling with Cox regression was used to obtain the sojourn time. Covariates were age at baseline, sex, amyloid status, and Alzheimer's disease (AD) or other dementia diagnosis. The sample included a register (SveDem) and memory clinics (Amsterdam Dementia Cohort and Memento). RESULTS: Using 80,543 patients, the sojourn time from clinically identified MCI to death across all patient groups ranged from 6.20 (95% confidence interval [CI]: 5.57–6.98) to 10.08 (8.94–12.18) years. DISCUSSION: Generally, sojourn time was inversely associated with older age at baseline, males, and AD diagnosis. The results provide key estimates for researchers and clinicians to estimate prognosis.
KW - Alzheimer's disease
KW - dementia
KW - epidemiology
KW - institutionalization
KW - mortality
KW - multi-state modeling
KW - multistate modeling
KW - sojourn times
UR - http://www.scopus.com/inward/record.url?scp=85173453094&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/alz.13488
DO - https://doi.org/10.1002/alz.13488
M3 - Article
C2 - 37779086
SN - 1552-5260
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
ER -