TY - JOUR
T1 - Prediction of future rheumatoid arthritis
AU - Turk, Samina A.
AU - van Beers-Tas, Marian H.
AU - van Schaardenburg, Dirkjan
N1 - Publisher Copyright: © 2014 Elsevier Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Rheumatoid arthritis (RA) results from an interaction between genetic susceptibility and environmental factors. Several of these factors are known, such as family history of RA, high birth weight, smoking, silica exposure, alcohol nonuse, obesity, diabetes mellitus, rheumatoid factor, anti-citrullinated protein antibody, and genetic variants such as the shared epitope and protein tyrosine phosphatase nonreceptor type 22. The impact of these factors can be modeled in the 2 main groups at risk of RA: family members of patients with RA and seropositive persons with or without arthralgia. Current models have the potential to select individuals for preventive strategies.
AB - Rheumatoid arthritis (RA) results from an interaction between genetic susceptibility and environmental factors. Several of these factors are known, such as family history of RA, high birth weight, smoking, silica exposure, alcohol nonuse, obesity, diabetes mellitus, rheumatoid factor, anti-citrullinated protein antibody, and genetic variants such as the shared epitope and protein tyrosine phosphatase nonreceptor type 22. The impact of these factors can be modeled in the 2 main groups at risk of RA: family members of patients with RA and seropositive persons with or without arthralgia. Current models have the potential to select individuals for preventive strategies.
KW - Arthralgia
KW - Autoantibodies
KW - Biomarkers
KW - Environmental
KW - Prediction
KW - Rheumatoid arthritis
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84908060741&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.rdc.2014.07.007
DO - https://doi.org/10.1016/j.rdc.2014.07.007
M3 - Review article
C2 - 25437290
SN - 0889-857X
VL - 40
SP - 753
EP - 770
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 4
ER -