Prediction of Walking Disability by Disease-Related Factors in Patients with Rheumatoid Arthritis

M. van der Leeden, R. Dahmen, J. Ursum, L.D. Roorda, D. van Schaardenburg, D.L. Knol, J. Dekker, M.P.M. Steultjens

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)


Objective: To investigate the relationship between diseaserelated factors and walking disability in different phases of rheumatoid arthritis; and to predict future walking disability in rheumatoid arthritis, using disease-related factors assessed 2 years after diagnosis. Methods: A cohort of 848 newly diagnosed patients with rheumatoid arthritis was followed up for a maximum of 8 years. Walking disability and several disease-related and demographic factors were recorded during follow-up. A logistic regression model was used to study associations between walking disability and these factors at different time points. A multilevel logistic regression model for longitudinal data was used to predict walking disability during follow-up from potential predictors at year 2. Results: Global pain and disease activity were consistently related to walking disability at almost every time point. Significant predictors of future walking disability were: walking disability, knee pain, global pain, the passage of time during follow-up, and age. Conclusion: Global pain and disease activity are related to walking disability during the first 8 years of RA. Walking disability, knee pain, and global pain at 2 years follow-up predict walking disability later in the disease. In addition, the risk for walking disability increases during the disease process and with higher age at diagnosis. © 2010 Foundation of Rehabilitation Information.
Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalJournal of rehabilitation medicine
Issue number5
Publication statusPublished - 2010

Cite this