TY - JOUR
T1 - Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy
T2 - The influence of maternal stress in pregnancy
AU - van den Bergh, Bea R. H.
AU - van den Heuvel, Marion I.
AU - Lahti, Marius
AU - Braeken, Marijke
AU - de Rooij, Susanne R.
AU - Entringer, Sonja
AU - Hoyer, Dirk
AU - Roseboom, Tessa
AU - Räikkönen, Katri
AU - King, Suzanne
AU - Schwab, Matthias
PY - 2020/10
Y1 - 2020/10
N2 - Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system
AB - Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system
KW - Journal Article
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=85028036596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028036596&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2017.07.003
DO - https://doi.org/10.1016/j.neubiorev.2017.07.003
M3 - Article
C2 - 28757456
SN - 0149-7634
VL - 117
SP - 26
EP - 64
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -
