TY - JOUR
T1 - Prevalence and validity of ACR/EULAR remission in four European early rheumatoid arthritis cohorts
AU - Britsemmer, Karin
AU - van Schaardenburg, Dirkjan
AU - Boers, Maarten
AU - de Cock, Diederik
AU - Verschueren, Patrick
AU - Radner, Helga
AU - Smolen, Josef S.
AU - van Tuyl, Lilian H. D.
PY - 2018
Y1 - 2018
N2 - Objective In 2011 an ACR/EULAR collaboration developed new remission definitions for RA. In the present study, we evaluated the prevalence and predictive validity of these new ACR/EULAR remission criteria in 4 different European early rheumatoid arthritis cohorts. Method Data from a tot al of 722 patients with early RA were analysed. Presence of remission at 6 months, as defined by one of the 4 proposed ACR/EULAR remission definitions was used to predict good functional and radiological outcome between 1 and 2 years of follow-up. Results Remission rates at 6 months ranged from 2-17% (Boolean definition) between the four cohorts. The level of HAQ and radiological damage varied between cohorts. Patients in remission at 6 months have an increased likelihood of long-term good outcome in terms of HAQ stability, but not radiographic stability. The performance of the practice definitions of remission was highly similar to the trial definitions. CRP status seems to add little information to the classification of remission in early RA. Conclusion In clinical practice, a minority of patients with early RA achieves remission in the first 6 months of treatment. Remission at 6 months is predictive for good HAQ outcome between year 1 and 2 after inclusion, but not radiographic stability.
AB - Objective In 2011 an ACR/EULAR collaboration developed new remission definitions for RA. In the present study, we evaluated the prevalence and predictive validity of these new ACR/EULAR remission criteria in 4 different European early rheumatoid arthritis cohorts. Method Data from a tot al of 722 patients with early RA were analysed. Presence of remission at 6 months, as defined by one of the 4 proposed ACR/EULAR remission definitions was used to predict good functional and radiological outcome between 1 and 2 years of follow-up. Results Remission rates at 6 months ranged from 2-17% (Boolean definition) between the four cohorts. The level of HAQ and radiological damage varied between cohorts. Patients in remission at 6 months have an increased likelihood of long-term good outcome in terms of HAQ stability, but not radiographic stability. The performance of the practice definitions of remission was highly similar to the trial definitions. CRP status seems to add little information to the classification of remission in early RA. Conclusion In clinical practice, a minority of patients with early RA achieves remission in the first 6 months of treatment. Remission at 6 months is predictive for good HAQ outcome between year 1 and 2 after inclusion, but not radiographic stability.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047095619&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29533752
M3 - Article
C2 - 29533752
SN - 0392-856X
VL - 36
SP - 362
EP - 370
JO - Clinical and experimental rheumatology
JF - Clinical and experimental rheumatology
IS - 3
ER -