Processing speed is related to striatal dopamine transporter availability in Parkinson's disease

Chris Vriend; Tim D van Balkom; Corné van Druningen; Martin Klein; Ysbrand D van der Werf; Henk W Berendse; Odile A van den Heuvel

doi:https://doi.org/10.1016/j.nicl.2020.102257

Processing speed is related to striatal dopamine transporter availability in Parkinson's disease

Chris Vriend, Tim D van Balkom, Corné van Druningen, Martin Klein, Ysbrand D van der Werf, Henk W Berendse, Odile A van den Heuvel

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

BACKGROUND: Parkinson's disease (PD) affects the integrity of the dopamine and serotonin system, and is characterized by a plethora of different symptoms, including cognitive impairments of which the pathophysiology is not yet fully elucidated.

OBJECTIVES: Investigate the role of the integrity of the dopaminergic and serotonergic system in cognitive functioning in early-stage PD using Single Photon Emission Computed Tomography (SPECT) combined with the radiotracer 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT).

METHODS: We studied the association between cognitive functions and dopamine transporter (DAT) availability in the caudate nucleus and putamen - as a proxy for striatal dopaminergic integrity - and serotonin transporter (SERT) availability as a proxy for serotonergic integrity in the thalamus and hippocampus using bootstrapped multiple regression. One-hundred-and-twenty-nine (129) PD patients underwent a 123I-FP-CIT SPECT scan and a neuropsychological assessment.

RESULTS: We showed a positive association between DAT availability in the head of the caudate nucleus and the Stroop Color Word Task - card I (reading words; β = 0.32, P = 0.001) and a positive association between DAT availability in the anterior putamen and the Trail Making Test part A (connecting consecutively numbered circles; β = 0.25, P = 0.02). These associations remained after adjusting for motor symptom severity or volume of the region-of-interest and were most pronounced in medication-naïve PD patients. There were no associations between cognitive performance and SERT availability in the thalamus or hippocampus.

CONCLUSIONS: We interpret these results as a role for striatal dopamine - and its PD-related decline - in aspects of processing speed.

Original language	English
Article number	102257
Pages (from-to)	102257
Journal	NeuroImage: Clinical
Volume	26
DOIs	https://doi.org/10.1016/j.nicl.2020.102257
Publication status	Published - 21 Apr 2020

Keywords

Cognition
Dopamine
Nuclear imaging
Parkinson
Serotonin
Striatum

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https://doi.org/10.1016/j.nicl.2020.102257

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@article{776466a6615d42a784a74c3d96b00d17,

title = "Processing speed is related to striatal dopamine transporter availability in Parkinson's disease",

abstract = "BACKGROUND: Parkinson's disease (PD) affects the integrity of the dopamine and serotonin system, and is characterized by a plethora of different symptoms, including cognitive impairments of which the pathophysiology is not yet fully elucidated.OBJECTIVES: Investigate the role of the integrity of the dopaminergic and serotonergic system in cognitive functioning in early-stage PD using Single Photon Emission Computed Tomography (SPECT) combined with the radiotracer 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT).METHODS: We studied the association between cognitive functions and dopamine transporter (DAT) availability in the caudate nucleus and putamen - as a proxy for striatal dopaminergic integrity - and serotonin transporter (SERT) availability as a proxy for serotonergic integrity in the thalamus and hippocampus using bootstrapped multiple regression. One-hundred-and-twenty-nine (129) PD patients underwent a 123I-FP-CIT SPECT scan and a neuropsychological assessment.RESULTS: We showed a positive association between DAT availability in the head of the caudate nucleus and the Stroop Color Word Task - card I (reading words; β = 0.32, P = 0.001) and a positive association between DAT availability in the anterior putamen and the Trail Making Test part A (connecting consecutively numbered circles; β = 0.25, P = 0.02). These associations remained after adjusting for motor symptom severity or volume of the region-of-interest and were most pronounced in medication-na{\"i}ve PD patients. There were no associations between cognitive performance and SERT availability in the thalamus or hippocampus.CONCLUSIONS: We interpret these results as a role for striatal dopamine - and its PD-related decline - in aspects of processing speed.",

keywords = "Cognition, Dopamine, Nuclear imaging, Parkinson, Serotonin, Striatum",

author = "Chris Vriend and {van Balkom}, {Tim D} and {van Druningen}, Corn{\'e} and Martin Klein and {van der Werf}, {Ysbrand D} and Berendse, {Henk W} and {van den Heuvel}, {Odile A}",

year = "2020",

month = apr,

day = "21",

doi = "https://doi.org/10.1016/j.nicl.2020.102257",

language = "English",

volume = "26",

pages = "102257",

journal = "NeuroImage: Clinical",

issn = "2213-1582",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Processing speed is related to striatal dopamine transporter availability in Parkinson's disease

AU - Vriend, Chris

AU - van Balkom, Tim D

AU - van Druningen, Corné

AU - Klein, Martin

AU - van der Werf, Ysbrand D

AU - Berendse, Henk W

AU - van den Heuvel, Odile A

PY - 2020/4/21

Y1 - 2020/4/21

N2 - BACKGROUND: Parkinson's disease (PD) affects the integrity of the dopamine and serotonin system, and is characterized by a plethora of different symptoms, including cognitive impairments of which the pathophysiology is not yet fully elucidated.OBJECTIVES: Investigate the role of the integrity of the dopaminergic and serotonergic system in cognitive functioning in early-stage PD using Single Photon Emission Computed Tomography (SPECT) combined with the radiotracer 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT).METHODS: We studied the association between cognitive functions and dopamine transporter (DAT) availability in the caudate nucleus and putamen - as a proxy for striatal dopaminergic integrity - and serotonin transporter (SERT) availability as a proxy for serotonergic integrity in the thalamus and hippocampus using bootstrapped multiple regression. One-hundred-and-twenty-nine (129) PD patients underwent a 123I-FP-CIT SPECT scan and a neuropsychological assessment.RESULTS: We showed a positive association between DAT availability in the head of the caudate nucleus and the Stroop Color Word Task - card I (reading words; β = 0.32, P = 0.001) and a positive association between DAT availability in the anterior putamen and the Trail Making Test part A (connecting consecutively numbered circles; β = 0.25, P = 0.02). These associations remained after adjusting for motor symptom severity or volume of the region-of-interest and were most pronounced in medication-naïve PD patients. There were no associations between cognitive performance and SERT availability in the thalamus or hippocampus.CONCLUSIONS: We interpret these results as a role for striatal dopamine - and its PD-related decline - in aspects of processing speed.

AB - BACKGROUND: Parkinson's disease (PD) affects the integrity of the dopamine and serotonin system, and is characterized by a plethora of different symptoms, including cognitive impairments of which the pathophysiology is not yet fully elucidated.OBJECTIVES: Investigate the role of the integrity of the dopaminergic and serotonergic system in cognitive functioning in early-stage PD using Single Photon Emission Computed Tomography (SPECT) combined with the radiotracer 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (123I-FP-CIT).METHODS: We studied the association between cognitive functions and dopamine transporter (DAT) availability in the caudate nucleus and putamen - as a proxy for striatal dopaminergic integrity - and serotonin transporter (SERT) availability as a proxy for serotonergic integrity in the thalamus and hippocampus using bootstrapped multiple regression. One-hundred-and-twenty-nine (129) PD patients underwent a 123I-FP-CIT SPECT scan and a neuropsychological assessment.RESULTS: We showed a positive association between DAT availability in the head of the caudate nucleus and the Stroop Color Word Task - card I (reading words; β = 0.32, P = 0.001) and a positive association between DAT availability in the anterior putamen and the Trail Making Test part A (connecting consecutively numbered circles; β = 0.25, P = 0.02). These associations remained after adjusting for motor symptom severity or volume of the region-of-interest and were most pronounced in medication-naïve PD patients. There were no associations between cognitive performance and SERT availability in the thalamus or hippocampus.CONCLUSIONS: We interpret these results as a role for striatal dopamine - and its PD-related decline - in aspects of processing speed.

KW - Cognition

KW - Dopamine

KW - Nuclear imaging

KW - Parkinson

KW - Serotonin

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=85083711830&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.nicl.2020.102257

DO - https://doi.org/10.1016/j.nicl.2020.102257

M3 - Article

C2 - 32344372

SN - 2213-1582

VL - 26

SP - 102257

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

M1 - 102257

ER -

Processing speed is related to striatal dopamine transporter availability in Parkinson's disease

Abstract

Keywords

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