@article{3a94840daa6a4570a8d6fe89b2fb433d,
title = "Progress in human picornavirus research: New findings from the AIROPico consortium",
abstract = "Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.",
keywords = "Antiviral therapy, Enterovirus, Pathogenesis, Picornavirus, Point of care (POC) diagnostics",
author = "Wolthers, {Katja C.} and Petri Susi and Dirk Jochmans and Janne Koskinen and Olfert Landt and Neus Sanchez and Kaia Palm and Johan Neyts and Butcher, {Sarah J.}",
note = "Funding Information: For their wonderful work done within the consortium we would like to thank all AIROPico fellows (in alphabetical order): Heli Aatola, Maria Anastasina, Andrea Bruning, Alexander am Ende, Justin Flatt, James Geraets, Cornelia G{\"o}tz, Eve Karelehto, Anri Kivil, Gerrit Koen, Ida Koho, Juha Koskinen, Pasi Laurinm{\"a}ki, Urmas Liivas, Carmen Mirabelli, Toomas Neuman, Susan Pihelgas, Arno Pihlak, Sabine van der Sanden, Els Scheers, Laura Teixido, Hendrik Jan Thibaut, Lav Tripathi, Brenda Westerhuis, and Maryse Wiewel. We thank Monica Jara (as the first Antibody BCN representative) for her great contributions to the network. We thank our scientific advisors Prof Renate Fuchs and Prof Frank van Kuppeveld for their guidance throughout the project. Lastly we would like to thank our project managers Frank Groen, Stella Koppel, Ram Venkatachalam and Laurian Jongejan for their tremendous support during the project. This work was financially supported by the European Union's Seventh Framework Marie-Curie IAPP AIROPico grant [ 612308 ]. Funding Information: For their wonderful work done within the consortium we would like to thank all AIROPico fellows (in alphabetical order): Heli Aatola, Maria Anastasina, Andrea Bruning, Alexander am Ende, Justin Flatt, James Geraets, Cornelia G{\"o}tz, Eve Karelehto, Anri Kivil, Gerrit Koen, Ida Koho, Juha Koskinen, Pasi Laurinm{\"a}ki, Urmas Liivas, Carmen Mirabelli, Toomas Neuman, Susan Pihelgas, Arno Pihlak, Sabine van der Sanden, Els Scheers, Laura Teixido, Hendrik Jan Thibaut, Lav Tripathi, Brenda Westerhuis, and Maryse Wiewel. We thank Monica Jara (as the first Antibody BCN representative) for her great contributions to the network. We thank our scientific advisors Prof Renate Fuchs and Prof Frank van Kuppeveld for their guidance throughout the project. Lastly we would like to thank our project managers Frank Groen, Stella Koppel, Ram Venkatachalam and Laurian Jongejan for their tremendous support during the project. This work was financially supported by the European Union's Seventh Framework Marie-Curie IAPP AIROPico grant [612308]. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2019",
month = jan,
doi = "https://doi.org/10.1016/j.antiviral.2018.11.010",
language = "English",
volume = "161",
pages = "100--107",
journal = "Antiviral Research",
issn = "0166-3542",
publisher = "Elsevier",
}