Prophylaxis for venous thromboembolism during asparaginase therapy in patients treated for acute lymphoblastic leukemia

This is the protocol for a review and there is no abstract. The objectives are as follows: Primary objectives of this review are: to investigate and summarize whether thromboprophylactic measures are effective in reducing the incidence of VTE during asparaginase therapy in primary ALL remission induction treatment for pediatric and adult patients; to investigate the impact of thromboprophylaxis used during primary ALL remission induction treatment on overall survival. Secondary objectives of this review are: to investigate and summarize the adverse effects of thromboprophylactic measures during asparaginase therapy in primary ALL remission induction treatment, to address their safety (Loke 2011); to investigate and summarize which thromboprophylactic measure is the most effective in reducing the VTE incidence during asparaginase therapy in primary ALL remission induction treatment; to investigate the impact of thromboprophylaxis used during asparaginase therapy in primary ALL remission induction treatment on ALL treatment outcome, expressed in complete remission rates.