@article{21bf1b9b0f7b4ca0a7fb220b6fb4eced,
title = "Quality control and conduct of genome-wide association meta-analyses",
abstract = "Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta- level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete",
author = "Winkler, {Thomas W.} and Day, {Felix R.} and Croteau-Chonka, {Damien C.} and Wood, {Andrew R.} and Locke, {Adam E.} and Reedik M{\"a}gi and Teresa Ferreira and Tove Fall and Mariaelisa Graff and Justice, {Anne E.} and Jian'an Luan and Stefan Gustafsson and Randall, {Joshua C.} and Sailaja Vedantam and Tsegaselassie Workalemahu and Kilpel{\"a}inen, {Tuomas O.} and Andr{\'e} Scherag and Tonu Esko and Zolt{\'a}n Kutalik and Heid, {Iris M.} and Loos, {Ruth J. F.} and {AUTHOR GROUP} and Abecasis, {Goncalo R.} and Devin Absher and Helene Alavere and Eva Albrecht and Allen, {Hana Lango} and Peter Almgren and Najaf Amin and Philippe Amouyel and Denise Anderson and Arnold, {Alice M.} and Dominique Arveiler and Thor Aspelund and Asselbergs, {Folkert W.} and Assimes, {Themistocles L.} and Mustafa Atalay and Attwood, {Antony P.} and Atwood, {Larry D.} and Bakker, {Stephan J. L.} and Beverley Balkau and Balmforth, {Anthony J.} and Cristina Barlassina and In{\^e}s Barroso and Hanneke Basart and Sabrina Bauer and Beckmann, {Jacques S.} and Beilby, {John P.} and Bennett, {Amanda J.} and Hovingh, {Kees G.} and Trip, {Mieke D.} and D.I. Boomsma and {de Geus}, E.J.C. and J.J. Hottenga and G. Willemsen and B.W.J.H. Penninx and J.H. Smit",
year = "2014",
doi = "https://doi.org/10.1038/nprot.2014.071",
language = "English",
volume = "9",
pages = "1192--1212",
journal = "Nature protocols",
issn = "1754-2189",
publisher = "Nature Publishing Group",
number = "5",
}
