Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

Sven F. Seys; Shana de Bont; Wytske J. Fokkens; Claus Bachert; Isam Alobid; Manuel Bernal-Sprekelsen; Leif Bjermer; Ina Callebaut; Lars-Olaf Cardell; Sean Carrie; Paolo Castelnuovo; Russell Cathcart; Jannis Constantinidis; Leen Cools; Marjolein Cornet; Gregory Clement; Tony Cox; Lieve Delsupehe; Jaime Correia-de-Sousa; Lauren Deneyer; Geert de Vos; Zuzana Diamant; Maria Doulaptsi; Simon Gane; Philippe Gevaert; Claire Hopkins; Valérie Hox; Thomas Hummel; Werner Hosemann; Raf Jacobs; Mark Jorissen; Anette Kjeldsen; Basile N. Landis; Winde Lemmens; Andreas Leunig; Valerie Lund; Gert Mariën; Joaquim Mullol; Metin Onerci; Susanna Palkonen; Isabel Proano; Emmanuel Prokopakis; Dermot Ryan; Herbert Riechelmann; Pernilla Sahlstrand-Johnson; Sanna Salmi-Toppila; Christine Segboer; Kato Speleman; Andreas Steinsvik; Pavol Surda; Peter-Valentin Tomazic; Olivier Vanderveken; Laura van Gerven; Thibaut van Zele; Jan Verfaillie; Benedicte Verhaeghe; Kathie Vierstraete; Stephan Vlaminck; Martin Wagenmann; Benoit Pugin; Peter W. Hellings

doi:https://doi.org/10.1111/all.14408

Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

Sven F. Seys, Shana de Bont, Wytske J. Fokkens, Claus Bachert, Isam Alobid, Manuel Bernal-Sprekelsen, Leif Bjermer, Ina Callebaut, Lars-Olaf Cardell, Sean Carrie, Paolo Castelnuovo, Russell Cathcart, Jannis Constantinidis, Leen Cools, Marjolein Cornet, Gregory Clement, Tony Cox, Lieve Delsupehe, Jaime Correia-de-Sousa, Lauren DeneyerGeert de Vos, Zuzana Diamant, Maria Doulaptsi, Simon Gane, Philippe Gevaert, Claire Hopkins, Valérie Hox, Thomas Hummel, Werner Hosemann, Raf Jacobs, Mark Jorissen, Anette Kjeldsen, Basile N. Landis, Winde Lemmens, Andreas Leunig, Valerie Lund, Gert Mariën, Joaquim Mullol, Metin Onerci, Susanna Palkonen, Isabel Proano, Emmanuel Prokopakis, Dermot Ryan, Herbert Riechelmann, Pernilla Sahlstrand-Johnson, Sanna Salmi-Toppila, Christine Segboer, Kato Speleman, Andreas Steinsvik, Pavol Surda, Peter-Valentin Tomazic, Olivier Vanderveken, Laura van Gerven, Thibaut van Zele, Jan Verfaillie, Benedicte Verhaeghe, Kathie Vierstraete, Stephan Vlaminck, Martin Wagenmann, Benoit Pugin, Peter W. Hellings

Research output: Contribution to journal › Article › Academic › peer-review

47 Citations (Scopus)

Abstract

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. Methods: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. Conclusion: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.

Original language	English
Pages (from-to)	2867-2878
Number of pages	12
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	75
Issue number	11
Early online date	2020
DOIs	https://doi.org/10.1111/all.14408
Publication status	Published - 1 Nov 2020

Keywords

Mobile health technology
nasal polyp
patient-reported outcome measure
real-world evidence
visual analogue scale

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https://doi.org/10.1111/all.14408

Cite this

Seys, S. F., de Bont, S., Fokkens, W. J., Bachert, C., Alobid, I., Bernal-Sprekelsen, M., Bjermer, L., Callebaut, I., Cardell, L.-O., Carrie, S., Castelnuovo, P., Cathcart, R., Constantinidis, J., Cools, L., Cornet, M., Clement, G., Cox, T., Delsupehe, L., Correia-de-Sousa, J., ... Hellings, P. W. (2020). Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA. Allergy: European Journal of Allergy and Clinical Immunology, 75(11), 2867-2878. https://doi.org/10.1111/all.14408

@article{f43a2e0654114cd090356417e9f34614,

title = "Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA",

abstract = "Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. Methods: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. Conclusion: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.",

keywords = "Mobile health technology, nasal polyp, patient-reported outcome measure, real-world evidence, visual analogue scale",

author = "Seys, {Sven F.} and {de Bont}, Shana and Fokkens, {Wytske J.} and Claus Bachert and Isam Alobid and Manuel Bernal-Sprekelsen and Leif Bjermer and Ina Callebaut and Lars-Olaf Cardell and Sean Carrie and Paolo Castelnuovo and Russell Cathcart and Jannis Constantinidis and Leen Cools and Marjolein Cornet and Gregory Clement and Tony Cox and Lieve Delsupehe and Jaime Correia-de-Sousa and Lauren Deneyer and {de Vos}, Geert and Zuzana Diamant and Maria Doulaptsi and Simon Gane and Philippe Gevaert and Claire Hopkins and Val{\'e}rie Hox and Thomas Hummel and Werner Hosemann and Raf Jacobs and Mark Jorissen and Anette Kjeldsen and Landis, {Basile N.} and Winde Lemmens and Andreas Leunig and Valerie Lund and Gert Mari{\"e}n and Joaquim Mullol and Metin Onerci and Susanna Palkonen and Isabel Proano and Emmanuel Prokopakis and Dermot Ryan and Herbert Riechelmann and Pernilla Sahlstrand-Johnson and Sanna Salmi-Toppila and Christine Segboer and Kato Speleman and Andreas Steinsvik and Pavol Surda and Peter-Valentin Tomazic and Olivier Vanderveken and {van Gerven}, Laura and {van Zele}, Thibaut and Jan Verfaillie and Benedicte Verhaeghe and Kathie Vierstraete and Stephan Vlaminck and Martin Wagenmann and Benoit Pugin and Hellings, {Peter W.}",

year = "2020",

month = nov,

day = "1",

doi = "https://doi.org/10.1111/all.14408",

language = "English",

volume = "75",

pages = "2867--2878",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell",

number = "11",

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Seys, SF, de Bont, S, Fokkens, WJ, Bachert, C, Alobid, I, Bernal-Sprekelsen, M, Bjermer, L, Callebaut, I, Cardell, L-O, Carrie, S, Castelnuovo, P, Cathcart, R, Constantinidis, J, Cools, L, Cornet, M, Clement, G, Cox, T, Delsupehe, L, Correia-de-Sousa, J, Deneyer, L, de Vos, G, Diamant, Z, Doulaptsi, M, Gane, S, Gevaert, P, Hopkins, C, Hox, V, Hummel, T, Hosemann, W, Jacobs, R, Jorissen, M, Kjeldsen, A, Landis, BN, Lemmens, W, Leunig, A, Lund, V, Mariën, G, Mullol, J, Onerci, M, Palkonen, S, Proano, I, Prokopakis, E, Ryan, D, Riechelmann, H, Sahlstrand-Johnson, P, Salmi-Toppila, S, Segboer, C, Speleman, K, Steinsvik, A, Surda, P, Tomazic, P-V, Vanderveken, O, van Gerven, L, van Zele, T, Verfaillie, J, Verhaeghe, B, Vierstraete, K, Vlaminck, S, Wagenmann, M, Pugin, B & Hellings, PW 2020, 'Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA', Allergy: European Journal of Allergy and Clinical Immunology, vol. 75, no. 11, pp. 2867-2878. https://doi.org/10.1111/all.14408

Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA. / Seys, Sven F.; de Bont, Shana; Fokkens, Wytske J. et al.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 75, No. 11, 01.11.2020, p. 2867-2878.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

AU - Seys, Sven F.

AU - de Bont, Shana

AU - Fokkens, Wytske J.

AU - Bachert, Claus

AU - Alobid, Isam

AU - Bernal-Sprekelsen, Manuel

AU - Bjermer, Leif

AU - Callebaut, Ina

AU - Cardell, Lars-Olaf

AU - Carrie, Sean

AU - Castelnuovo, Paolo

AU - Cathcart, Russell

AU - Constantinidis, Jannis

AU - Cools, Leen

AU - Cornet, Marjolein

AU - Clement, Gregory

AU - Cox, Tony

AU - Delsupehe, Lieve

AU - Correia-de-Sousa, Jaime

AU - Deneyer, Lauren

AU - de Vos, Geert

AU - Diamant, Zuzana

AU - Doulaptsi, Maria

AU - Gane, Simon

AU - Gevaert, Philippe

AU - Hopkins, Claire

AU - Hox, Valérie

AU - Hummel, Thomas

AU - Hosemann, Werner

AU - Jacobs, Raf

AU - Jorissen, Mark

AU - Kjeldsen, Anette

AU - Landis, Basile N.

AU - Lemmens, Winde

AU - Leunig, Andreas

AU - Lund, Valerie

AU - Mariën, Gert

AU - Mullol, Joaquim

AU - Onerci, Metin

AU - Palkonen, Susanna

AU - Proano, Isabel

AU - Prokopakis, Emmanuel

AU - Ryan, Dermot

AU - Riechelmann, Herbert

AU - Sahlstrand-Johnson, Pernilla

AU - Salmi-Toppila, Sanna

AU - Segboer, Christine

AU - Speleman, Kato

AU - Steinsvik, Andreas

AU - Surda, Pavol

AU - Tomazic, Peter-Valentin

AU - Vanderveken, Olivier

AU - van Gerven, Laura

AU - van Zele, Thibaut

AU - Verfaillie, Jan

AU - Verhaeghe, Benedicte

AU - Vierstraete, Kathie

AU - Vlaminck, Stephan

AU - Wagenmann, Martin

AU - Pugin, Benoit

AU - Hellings, Peter W.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. Methods: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. Conclusion: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.

AB - Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. Methods: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. Conclusion: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.

KW - Mobile health technology

KW - nasal polyp

KW - patient-reported outcome measure

KW - real-world evidence

KW - visual analogue scale

UR - http://www.scopus.com/inward/record.url?scp=85087117443&partnerID=8YFLogxK

U2 - https://doi.org/10.1111/all.14408

DO - https://doi.org/10.1111/all.14408

M3 - Article

C2 - 32424899

SN - 0105-4538

VL - 75

SP - 2867

EP - 2878

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 11

ER -

Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

Abstract

Keywords

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