Abstract
In 22 patients with malignancies, treated with high-dose chemoradiotherapy and autologous bone marrow transplantation (BMT), peripheral blood T cell subsets and functions were studied. In ten cytomegalovirus (CMV)-negative patients, CD4+ and CD8+ T cells (representing T cells of the helper/inducer phenotype and T cells of the suppressor/cytotoxic phenotype, respectively), recovered slowly and simultaneously. In 12 CMV-positive patients, however, CD8+ T cells recovered more rapidly than CD4+ T cells and rose to increased counts. No T cells with an immature phenotype (CD1+, OKT6+) were observed. Lymphocyte stimulation by herpes simplex virus infected fibroblasts (and by CMV-infected fibroblasts in CMV-positive patients) in contrast remained high and even increased after BMT in both groups. These data indicate that T cell recovery after autologous BMT is mainly due to proliferation of mature T cells present in the BM graft and not to generation of new T cells from T cell precursors.
Original language | English |
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Pages (from-to) | 428-31 |
Number of pages | 4 |
Journal | Blood |
Volume | 66 |
Issue number | 2 |
Publication status | Published - Aug 1985 |
Keywords
- Antibodies, Viral
- Antineoplastic Combined Chemotherapy Protocols
- Bone Marrow
- Bone Marrow Transplantation
- Cell Division
- Cells, Cultured
- Cytomegalovirus
- Cytomegalovirus Infections
- Follow-Up Studies
- Humans
- Journal Article
- Lymphocyte Activation
- Neoplasms
- Research Support, Non-U.S. Gov't
- Simplexvirus
- T-Lymphocytes
- Whole-Body Irradiation