TY - JOUR
T1 - Regulatory aspects of the human hypothalamus-pituitary-thyroid axis
AU - Roelfsema, Ferdinand
AU - Boelen, Anita
AU - Kalsbeek, Andries
AU - Fliers, Eric
PY - 2017
Y1 - 2017
N2 - Thyroid hormones are essential for growth, differentiation and metabolism during prenatal and postnatal life. The hypothalamus-pituitary -thyroid (HPT)-axis is optimized for these actions. Knowledge of this hormonal axis is derived from decades of experiments in animals and man, and more recently from spontaneous mutations in man and constructed mutations in mice. This review examines the HPT-axis in relation to 24 h TSH profiles in men in various physiological and pathophysiological conditions, including obesity, age, longevity, and primary as well as central hypothyroidism. Hormone rhythms can be analyzed by quantitative methods, e.g. operator-independent deconvolution, approximate entropy and fitting the 24-h component by Cosinor analysis or related procedures. These approaches have identified some of the regulatory components in (patho)physiological conditions. (C) 2017 Elsevier Ltd. All rights reserved
AB - Thyroid hormones are essential for growth, differentiation and metabolism during prenatal and postnatal life. The hypothalamus-pituitary -thyroid (HPT)-axis is optimized for these actions. Knowledge of this hormonal axis is derived from decades of experiments in animals and man, and more recently from spontaneous mutations in man and constructed mutations in mice. This review examines the HPT-axis in relation to 24 h TSH profiles in men in various physiological and pathophysiological conditions, including obesity, age, longevity, and primary as well as central hypothyroidism. Hormone rhythms can be analyzed by quantitative methods, e.g. operator-independent deconvolution, approximate entropy and fitting the 24-h component by Cosinor analysis or related procedures. These approaches have identified some of the regulatory components in (patho)physiological conditions. (C) 2017 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.beem.2017.09.004
DO - https://doi.org/10.1016/j.beem.2017.09.004
M3 - Article
C2 - 29223283
SN - 1521-690X
VL - 31
SP - 487
EP - 503
JO - Best practice & research. Clinical endocrinology & metabolism
JF - Best practice & research. Clinical endocrinology & metabolism
IS - 5 1
ER -