Relevance of mast cell-nerve interactions in intestinal nociception

Sophie A. van Diest; Oana I. Stanisor; Guy E. Boeckxstaens; Wouter J. de Jonge; René M. van den Wijngaard

doi:https://doi.org/10.1016/j.bbadis.2011.03.019

Relevance of mast cell-nerve interactions in intestinal nociception

Sophie A. van Diest, Oana I. Stanisor, Guy E. Boeckxstaens, Wouter J. de Jonge, René M. van den Wijngaard

Research output: Contribution to journal › Review article › Academic › peer-review

79 Citations (Scopus)

Abstract

Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception. as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2011 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	74-84
Journal	Biochimica et Biophysica Acta-Molecular Basis of Disease
Volume	1822
Issue number	1
DOIs	https://doi.org/10.1016/j.bbadis.2011.03.019
Publication status	Published - 2012

Access to Document

https://doi.org/10.1016/j.bbadis.2011.03.019

Cite this

@article{cbbb34ff08cc482682d7d2d3ecb61148,

title = "Relevance of mast cell-nerve interactions in intestinal nociception",

abstract = "Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception. as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2011 Elsevier B.V. All rights reserved",

author = "{van Diest}, {Sophie A.} and Stanisor, {Oana I.} and Boeckxstaens, {Guy E.} and {de Jonge}, {Wouter J.} and {van den Wijngaard}, {Ren{\'e} M.}",

year = "2012",

doi = "https://doi.org/10.1016/j.bbadis.2011.03.019",

language = "English",

volume = "1822",

pages = "74--84",

journal = "Biochimica et Biophysica Acta-Molecular Basis of Disease",

issn = "0925-4439",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Relevance of mast cell-nerve interactions in intestinal nociception

AU - van Diest, Sophie A.

AU - Stanisor, Oana I.

AU - Boeckxstaens, Guy E.

AU - de Jonge, Wouter J.

AU - van den Wijngaard, René M.

PY - 2012

Y1 - 2012

N2 - Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception. as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2011 Elsevier B.V. All rights reserved

AB - Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception. as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2011 Elsevier B.V. All rights reserved

U2 - https://doi.org/10.1016/j.bbadis.2011.03.019

DO - https://doi.org/10.1016/j.bbadis.2011.03.019

M3 - Review article

C2 - 21496484

SN - 0925-4439

VL - 1822

SP - 74

EP - 84

JO - Biochimica et Biophysica Acta-Molecular Basis of Disease

JF - Biochimica et Biophysica Acta-Molecular Basis of Disease

IS - 1

ER -