TY - JOUR
T1 - Repeatability of parametric methods for [18F]florbetapir imaging in Alzheimer’s disease and healthy controls
T2 - A test–retest study
AU - Verfaillie, Sander C. J.
AU - Golla, Sandeep S. V.
AU - Timmers, Tessa
AU - Tuncel, Hayel
AU - van der Weijden, Chris W. J.
AU - Schober, Patrick
AU - Schuit, Robert C.
AU - van der Flier, Wiesje M.
AU - Windhorst, Albert D.
AU - Lammertsma, Adriaan A.
AU - van Berckel, Bart N. M.
AU - Boellaard, Ronald
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Accumulation of amyloid beta (Aβ) is one of the pathological hallmarks of Alzheimer’s disease (AD), which can be visualized using [18F]florbetapir positron emission tomography (PET). The aim of this study was to evaluate various parametric methods and to assess their test-retest (TRT) reliability. Two 90 min dynamic [18F]florbetapir PET scans, including arterial sampling, were acquired (n = 8 AD patient, n = 8 controls). The following parametric methods were used; (reference:cerebellum); Logan and spectral analysis (SA), receptor parametric mapping (RPM), simplified reference tissue model2 (SRTM2), reference Logan (rLogan) and standardized uptake value ratios (SUVr(50–70)). BPND+1, DVR, VT and SUVr were compared with corresponding estimates (VT or DVR) from the plasma input reversible two tissue compartmental (2T4k_VB) model with corresponding TRT values for 90-scan duration. RPM (r2 = 0.92; slope = 0.91), Logan (r2 = 0.95; slope = 0.84) and rLogan (r2 = 0.94; slope = 0.88), and SRTM2 (r2 = 0.91; slope = 0.83), SA (r2 = 0.91; slope = 0.88), SUVr (r2 = 0.84; slope = 1.16) correlated well with their 2T4k_VB counterparts. RPM (controls: 1%, AD: 3%), rLogan (controls: 1%, AD: 3%) and SUVr(50–70) (controls: 3%, AD: 8%) showed an excellent TRT reliability. In conclusion, most parametric methods showed excellent performance for [18F]florbetapir, but RPM and rLogan seem the methods of choice, combining the highest accuracy and best TRT reliability.
AB - Accumulation of amyloid beta (Aβ) is one of the pathological hallmarks of Alzheimer’s disease (AD), which can be visualized using [18F]florbetapir positron emission tomography (PET). The aim of this study was to evaluate various parametric methods and to assess their test-retest (TRT) reliability. Two 90 min dynamic [18F]florbetapir PET scans, including arterial sampling, were acquired (n = 8 AD patient, n = 8 controls). The following parametric methods were used; (reference:cerebellum); Logan and spectral analysis (SA), receptor parametric mapping (RPM), simplified reference tissue model2 (SRTM2), reference Logan (rLogan) and standardized uptake value ratios (SUVr(50–70)). BPND+1, DVR, VT and SUVr were compared with corresponding estimates (VT or DVR) from the plasma input reversible two tissue compartmental (2T4k_VB) model with corresponding TRT values for 90-scan duration. RPM (r2 = 0.92; slope = 0.91), Logan (r2 = 0.95; slope = 0.84) and rLogan (r2 = 0.94; slope = 0.88), and SRTM2 (r2 = 0.91; slope = 0.83), SA (r2 = 0.91; slope = 0.88), SUVr (r2 = 0.84; slope = 1.16) correlated well with their 2T4k_VB counterparts. RPM (controls: 1%, AD: 3%), rLogan (controls: 1%, AD: 3%) and SUVr(50–70) (controls: 3%, AD: 8%) showed an excellent TRT reliability. In conclusion, most parametric methods showed excellent performance for [18F]florbetapir, but RPM and rLogan seem the methods of choice, combining the highest accuracy and best TRT reliability.
KW - Alzheimer’s disease
KW - Amyloid PET
KW - PET quantification
KW - [F]florbetapir
KW - parametric imaging methods
KW - test–retest design
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083786838&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/32321347
UR - http://www.scopus.com/inward/record.url?scp=85083786838&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/0271678X20915403
DO - https://doi.org/10.1177/0271678X20915403
M3 - Article
C2 - 32321347
SN - 0271-678X
VL - 41
SP - 569
EP - 578
JO - Journal of cerebral blood flow and metabolism
JF - Journal of cerebral blood flow and metabolism
IS - 3
ER -