TY - JOUR
T1 - Repressing the repressor: Ezh2 mediates macrophage activation
AU - Neele, Annette E.
AU - de Winther, Menno P. J.
PY - 2018
Y1 - 2018
N2 - In this issue of JEM, Zhang et al. (https:// doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease.
AB - In this issue of JEM, Zhang et al. (https:// doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046804960&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29691302
U2 - https://doi.org/10.1084/jem.20180479
DO - https://doi.org/10.1084/jem.20180479
M3 - Comment/Letter to the editor
C2 - 29691302
SN - 0022-1007
VL - 215
SP - 1269
EP - 1271
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -